Sex-dependent differences in the pharmacological actions and pharmacokinetics of phencyclidine in rats

Toshitaka Nabeshima, Kazumasa Yamaguchi, Kiyofumi Yamada, Masayuki Hiramatsu, Yoshibumi Kuwabara, Hiroshi Furukawa, Tsutomu Kameyama

研究成果: ジャーナルへの寄稿学術論文査読

55 被引用数 (Scopus)

抄録

This study was designed to assess the sex differences in phencyclidine(PCP)-induced ambulatory activity in an open-field, stereotyped behaviors, motor incoordination, tremor, salivation, the regional and subcellular distributions of PCP in the brain and the half-life of PCP in the brain and plasma. Female rats appeared to be more sensitive to PCP as evidenced by hyperactivity, stereotyped behaviors, motor incoordination, tremor, salivation and ataxia. The concentrations of PCP in female rat brain were higher than in the male rats in some discrete brain areas and subcellular fractions. The half-life of PCP in the brain and plasma was longer in female rats than in male rats. The inverse relationship of pharmacological responses to PCP and biotransformation of PCP in both sexes of rats suggests that sex differences in pharmacological actions of PCP depend largely on differences in ability to biotransform the drug.

本文言語英語
ページ(範囲)217-227
ページ数11
ジャーナルEuropean Journal of Pharmacology
97
3-4
DOI
出版ステータス出版済み - 27-01-1984
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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