TY - JOUR
T1 - Sex-dependent differences in the pharmacological actions and pharmacokinetics of phencyclidine in rats
AU - Nabeshima, Toshitaka
AU - Yamaguchi, Kazumasa
AU - Yamada, Kiyofumi
AU - Hiramatsu, Masayuki
AU - Kuwabara, Yoshibumi
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
N1 - Funding Information:
This work was supported in part by grant No. 57570089 from the Ministry of Education, Science and Culture, Japan to T.N.
PY - 1984/1/27
Y1 - 1984/1/27
N2 - This study was designed to assess the sex differences in phencyclidine(PCP)-induced ambulatory activity in an open-field, stereotyped behaviors, motor incoordination, tremor, salivation, the regional and subcellular distributions of PCP in the brain and the half-life of PCP in the brain and plasma. Female rats appeared to be more sensitive to PCP as evidenced by hyperactivity, stereotyped behaviors, motor incoordination, tremor, salivation and ataxia. The concentrations of PCP in female rat brain were higher than in the male rats in some discrete brain areas and subcellular fractions. The half-life of PCP in the brain and plasma was longer in female rats than in male rats. The inverse relationship of pharmacological responses to PCP and biotransformation of PCP in both sexes of rats suggests that sex differences in pharmacological actions of PCP depend largely on differences in ability to biotransform the drug.
AB - This study was designed to assess the sex differences in phencyclidine(PCP)-induced ambulatory activity in an open-field, stereotyped behaviors, motor incoordination, tremor, salivation, the regional and subcellular distributions of PCP in the brain and the half-life of PCP in the brain and plasma. Female rats appeared to be more sensitive to PCP as evidenced by hyperactivity, stereotyped behaviors, motor incoordination, tremor, salivation and ataxia. The concentrations of PCP in female rat brain were higher than in the male rats in some discrete brain areas and subcellular fractions. The half-life of PCP in the brain and plasma was longer in female rats than in male rats. The inverse relationship of pharmacological responses to PCP and biotransformation of PCP in both sexes of rats suggests that sex differences in pharmacological actions of PCP depend largely on differences in ability to biotransform the drug.
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U2 - 10.1016/0014-2999(84)90453-9
DO - 10.1016/0014-2999(84)90453-9
M3 - Article
C2 - 6538506
AN - SCOPUS:0021367798
VL - 97
SP - 217
EP - 227
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3-4
ER -