Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry

Tommaso Bucci; Alena Shantsila; Giulio Francesco Romiti; Wee Siong Teo; Hyung Wook Park; Wataru Shimizu; Davide Antonio Mei; Hung Fat Tse; Marco Proietti; Tze Fan Chao; Gregory Y.H. Lip; Chun Wah Siu David; Wataru Shimizu; Kenji Yodogawa; Hiroyuki Tsutsui; Yasushi Mukai; Hirofumi Tomita; Daisuke Horiuchi; Joji Hagii; Kazutaka Aonuma; Yasuo Okumura; Masahiko Goya; Kenzo Hirao; Masayoshi Ajioka; Nobuhisa Hagiwara; Atsushi Suzuki; Teiichi Yamane; Takanori Ikeda; Hitomi Yuzawa; Kazuhiro Satomi; Yoshinao Yazaki; Keiichi Fukuda; Yoshinori Kobayashi; Norishige Morita; Toyoaki Murohara; Eiichi Watanabe; Masahide Harada; Satoru Sakagami; Takahiro Saeki; Kengo Kusano; Koji Miyamoto; Shinsuke Miyazaki; Hiroshi Tada; Koichi Inoue; Nobuaki Tanaka; Yukihiro Koretsune; Haruhiko Abe; Yasuki Kihara; Yukiko Nakano; Akihiko Shimizu; Yasuhiro Yoshiga; Tomohiro Sakamoto; Ken Okumur; Naohiko Takahashi; Tetsuji Shinohara; Kyoko Soejima; Masahiko Takagi; Mitsuharu Kawamura; Yumi Munetsugu; Sung Hwan Kim; Jae Min Shim; Jae Sun Uhm; Sung Il Im; Hyoung Seob Par; Jun Hyung Kim; Young Keun On; Il Young Oh; Seung Yong Shin; Jum Suk Ko; Jun Beom Park; Wee Siong Teo; Kelvin Cheok Keng Won; Toon Wei Lim; David Foo; Shih Ann Chen; Tze Fan Chao; Yenn Jiang Lin; Fa Po Chung; Yu Feng Hu; Shil Lin Chang; Ta Chuan Tuan; Jo Nan Liao; Cheng Hung Li; Jin Long Huang; Yu Cheng Hsieh; Tsu Juey Wu; Ying Chieh Liao; Hsiang Chiang Hsiao; Tung Chen Yeh; Wei Siang Lin; Wen Yu Lin; Jen Yuan Kuo; Chong Lie Hong; Yih Je Wu; Ying Siang Li; Jui Peng Tsai; Kuo Tzu Sung; Sheng Hsiung Chang

doi:10.1038/s41598-023-45345-3

Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry

Tommaso Bucci, Alena Shantsila, Giulio Francesco Romiti, Wee Siong Teo, Hyung Wook Park, Wataru Shimizu, Davide Antonio Mei, Hung Fat Tse, Marco Proietti, Tze Fan Chao, Gregory Y.H. Lip, Chun Wah Siu David, Wataru Shimizu, Kenji Yodogawa, Hiroyuki Tsutsui, Yasushi Mukai, Hirofumi Tomita, Daisuke Horiuchi, Joji Hagii, Kazutaka AonumaYasuo Okumura, Masahiko Goya, Kenzo Hirao, Masayoshi Ajioka, Nobuhisa Hagiwara, Atsushi Suzuki, Teiichi Yamane, Takanori Ikeda, Hitomi Yuzawa, Kazuhiro Satomi, Yoshinao Yazaki, Keiichi Fukuda, Yoshinori Kobayashi, Norishige Morita, Toyoaki Murohara, Eiichi Watanabe, Masahide Harada, Satoru Sakagami, Takahiro Saeki, Kengo Kusano, Koji Miyamoto, Shinsuke Miyazaki, Hiroshi Tada, Koichi Inoue, Nobuaki Tanaka, Yukihiro Koretsune, Haruhiko Abe, Yasuki Kihara, Yukiko Nakano, Akihiko Shimizu, Yasuhiro Yoshiga, Tomohiro Sakamoto, Ken Okumur, Naohiko Takahashi, Tetsuji Shinohara, Kyoko Soejima, Masahiko Takagi, Mitsuharu Kawamura, Yumi Munetsugu, Sung Hwan Kim, Jae Min Shim, Jae Sun Uhm, Sung Il Im, Hyoung Seob Par, Jun Hyung Kim, Young Keun On, Il Young Oh, Seung Yong Shin, Jum Suk Ko, Jun Beom Park, Wee Siong Teo, Kelvin Cheok Keng Won, Toon Wei Lim, David Foo, Shih Ann Chen, Tze Fan Chao, Yenn Jiang Lin, Fa Po Chung, Yu Feng Hu, Shil Lin Chang, Ta Chuan Tuan, Jo Nan Liao, Cheng Hung Li, Jin Long Huang, Yu Cheng Hsieh, Tsu Juey Wu, Ying Chieh Liao, Hsiang Chiang Hsiao, Tung Chen Yeh, Wei Siang Lin, Wen Yu Lin, Jen Yuan Kuo, Chong Lie Hong, Yih Je Wu, Ying Siang Li, Jui Peng Tsai, Kuo Tzu Sung, Sheng Hsiung Chang

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

抄録

We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia–Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 ± 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 ± 11 vs 67 ± 12 years, p < 0.001) and dyslipidemia (36.7% vs 41.7%, p = 0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p < 0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p = 0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38–0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22–0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences.

本文言語	英語
論文番号	18375
ジャーナル	Scientific reports
巻	13
号	1
DOI	https://doi.org/10.1038/s41598-023-45345-3
出版ステータス	出版済み - 12-2023

All Science Journal Classification (ASJC) codes

一般

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10.1038/s41598-023-45345-3

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引用スタイル

Bucci, T., Shantsila, A., Romiti, G. F., Teo, W. S., Park, H. W., Shimizu, W., Mei, D. A., Tse, H. F., Proietti, M., Chao, T. F., Lip, G. Y. H., David, C. W. S., Shimizu, W., Yodogawa, K., Tsutsui, H., Mukai, Y., Tomita, H., Horiuchi, D., Hagii, J., ... Chang, S. H. (2023). Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry. Scientific reports, 13(1), 記事 18375. https://doi.org/10.1038/s41598-023-45345-3

@article{4f8259504bb04eaba5277a749fbdb19e,

title = "Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry",

abstract = "We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia–Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 ± 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 ± 11 vs 67 ± 12 years, p < 0.001) and dyslipidemia (36.7% vs 41.7%, p = 0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p < 0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p = 0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38–0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22–0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences.",

author = "Tommaso Bucci and Alena Shantsila and Romiti, {Giulio Francesco} and Teo, {Wee Siong} and Park, {Hyung Wook} and Wataru Shimizu and Mei, {Davide Antonio} and Tse, {Hung Fat} and Marco Proietti and Chao, {Tze Fan} and Lip, {Gregory Y.H.} and David, {Chun Wah Siu} and Wataru Shimizu and Kenji Yodogawa and Hiroyuki Tsutsui and Yasushi Mukai and Hirofumi Tomita and Daisuke Horiuchi and Joji Hagii and Kazutaka Aonuma and Yasuo Okumura and Masahiko Goya and Kenzo Hirao and Masayoshi Ajioka and Nobuhisa Hagiwara and Atsushi Suzuki and Teiichi Yamane and Takanori Ikeda and Hitomi Yuzawa and Kazuhiro Satomi and Yoshinao Yazaki and Keiichi Fukuda and Yoshinori Kobayashi and Norishige Morita and Toyoaki Murohara and Eiichi Watanabe and Masahide Harada and Satoru Sakagami and Takahiro Saeki and Kengo Kusano and Koji Miyamoto and Shinsuke Miyazaki and Hiroshi Tada and Koichi Inoue and Nobuaki Tanaka and Yukihiro Koretsune and Haruhiko Abe and Yasuki Kihara and Yukiko Nakano and Akihiko Shimizu and Yasuhiro Yoshiga and Tomohiro Sakamoto and Ken Okumur and Naohiko Takahashi and Tetsuji Shinohara and Kyoko Soejima and Masahiko Takagi and Mitsuharu Kawamura and Yumi Munetsugu and Kim, {Sung Hwan} and Shim, {Jae Min} and Uhm, {Jae Sun} and Im, {Sung Il} and Par, {Hyoung Seob} and Kim, {Jun Hyung} and On, {Young Keun} and Oh, {Il Young} and Shin, {Seung Yong} and Ko, {Jum Suk} and Park, {Jun Beom} and Teo, {Wee Siong} and Won, {Kelvin Cheok Keng} and Lim, {Toon Wei} and David Foo and Chen, {Shih Ann} and Chao, {Tze Fan} and Lin, {Yenn Jiang} and Chung, {Fa Po} and Hu, {Yu Feng} and Chang, {Shil Lin} and Tuan, {Ta Chuan} and Liao, {Jo Nan} and Li, {Cheng Hung} and Huang, {Jin Long} and Hsieh, {Yu Cheng} and Wu, {Tsu Juey} and Liao, {Ying Chieh} and Hsiao, {Hsiang Chiang} and Yeh, {Tung Chen} and Lin, {Wei Siang} and Lin, {Wen Yu} and Kuo, {Jen Yuan} and Hong, {Chong Lie} and Wu, {Yih Je} and Li, {Ying Siang} and Tsai, {Jui Peng} and Sung, {Kuo Tzu} and Chang, {Sheng Hsiung}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = dec,

doi = "10.1038/s41598-023-45345-3",

language = "English",

volume = "13",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

Bucci, T, Shantsila, A, Romiti, GF, Teo, WS, Park, HW, Shimizu, W, Mei, DA, Tse, HF, Proietti, M, Chao, TF, Lip, GYH, David, CWS, Shimizu, W, Yodogawa, K, Tsutsui, H, Mukai, Y, Tomita, H, Horiuchi, D, Hagii, J, Aonuma, K, Okumura, Y, Goya, M, Hirao, K, Ajioka, M, Hagiwara, N, Suzuki, A, Yamane, T, Ikeda, T, Yuzawa, H, Satomi, K, Yazaki, Y, Fukuda, K, Kobayashi, Y, Morita, N, Murohara, T, Watanabe, E , Harada, M, Sakagami, S, Saeki, T, Kusano, K, Miyamoto, K, Miyazaki, S, Tada, H, Inoue, K, Tanaka, N, Koretsune, Y, Abe, H, Kihara, Y, Nakano, Y, Shimizu, A, Yoshiga, Y, Sakamoto, T, Okumur, K, Takahashi, N, Shinohara, T, Soejima, K, Takagi, M, Kawamura, M, Munetsugu, Y, Kim, SH, Shim, JM, Uhm, JS, Im, SI, Par, HS, Kim, JH, On, YK, Oh, IY, Shin, SY, Ko, JS, Park, JB, Teo, WS, Won, KCK, Lim, TW, Foo, D, Chen, SA, Chao, TF, Lin, YJ, Chung, FP, Hu, YF, Chang, SL, Tuan, TC, Liao, JN, Li, CH, Huang, JL, Hsieh, YC, Wu, TJ, Liao, YC, Hsiao, HC, Yeh, TC, Lin, WS, Lin, WY, Kuo, JY, Hong, CL, Wu, YJ, Li, YS, Tsai, JP, Sung, KT & Chang, SH 2023, 'Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry', Scientific reports, vol. 13, no. 1, 18375. https://doi.org/10.1038/s41598-023-45345-3

TY - JOUR

T1 - Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation

T2 - a report from the prospective APHRS-AF Registry

AU - Bucci, Tommaso

AU - Shantsila, Alena

AU - Romiti, Giulio Francesco

AU - Teo, Wee Siong

AU - Park, Hyung Wook

AU - Shimizu, Wataru

AU - Mei, Davide Antonio

AU - Tse, Hung Fat

AU - Proietti, Marco

AU - Chao, Tze Fan

AU - Lip, Gregory Y.H.

AU - David, Chun Wah Siu

AU - Shimizu, Wataru

AU - Yodogawa, Kenji

AU - Tsutsui, Hiroyuki

AU - Mukai, Yasushi

AU - Tomita, Hirofumi

AU - Horiuchi, Daisuke

AU - Hagii, Joji

AU - Aonuma, Kazutaka

AU - Okumura, Yasuo

AU - Goya, Masahiko

AU - Hirao, Kenzo

AU - Ajioka, Masayoshi

AU - Hagiwara, Nobuhisa

AU - Suzuki, Atsushi

AU - Yamane, Teiichi

AU - Ikeda, Takanori

AU - Yuzawa, Hitomi

AU - Satomi, Kazuhiro

AU - Yazaki, Yoshinao

AU - Fukuda, Keiichi

AU - Kobayashi, Yoshinori

AU - Morita, Norishige

AU - Murohara, Toyoaki

AU - Watanabe, Eiichi

AU - Harada, Masahide

AU - Sakagami, Satoru

AU - Saeki, Takahiro

AU - Kusano, Kengo

AU - Miyamoto, Koji

AU - Miyazaki, Shinsuke

AU - Tada, Hiroshi

AU - Inoue, Koichi

AU - Tanaka, Nobuaki

AU - Koretsune, Yukihiro

AU - Abe, Haruhiko

AU - Kihara, Yasuki

AU - Nakano, Yukiko

AU - Shimizu, Akihiko

AU - Yoshiga, Yasuhiro

AU - Sakamoto, Tomohiro

AU - Okumur, Ken

AU - Takahashi, Naohiko

AU - Shinohara, Tetsuji

AU - Soejima, Kyoko

AU - Takagi, Masahiko

AU - Kawamura, Mitsuharu

AU - Munetsugu, Yumi

AU - Kim, Sung Hwan

AU - Shim, Jae Min

AU - Uhm, Jae Sun

AU - Im, Sung Il

AU - Par, Hyoung Seob

AU - Kim, Jun Hyung

AU - On, Young Keun

AU - Oh, Il Young

AU - Shin, Seung Yong

AU - Ko, Jum Suk

AU - Park, Jun Beom

AU - Teo, Wee Siong

AU - Won, Kelvin Cheok Keng

AU - Lim, Toon Wei

AU - Foo, David

AU - Chen, Shih Ann

AU - Chao, Tze Fan

AU - Lin, Yenn Jiang

AU - Chung, Fa Po

AU - Hu, Yu Feng

AU - Chang, Shil Lin

AU - Tuan, Ta Chuan

AU - Liao, Jo Nan

AU - Li, Cheng Hung

AU - Huang, Jin Long

AU - Hsieh, Yu Cheng

AU - Wu, Tsu Juey

AU - Liao, Ying Chieh

AU - Hsiao, Hsiang Chiang

AU - Yeh, Tung Chen

AU - Lin, Wei Siang

AU - Lin, Wen Yu

AU - Kuo, Jen Yuan

AU - Hong, Chong Lie

AU - Wu, Yih Je

AU - Li, Ying Siang

AU - Tsai, Jui Peng

AU - Sung, Kuo Tzu

AU - Chang, Sheng Hsiung

PY - 2023/12

Y1 - 2023/12

N2 - We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia–Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 ± 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 ± 11 vs 67 ± 12 years, p < 0.001) and dyslipidemia (36.7% vs 41.7%, p = 0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p < 0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p = 0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38–0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22–0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences.

AB - We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia–Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 ± 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 ± 11 vs 67 ± 12 years, p < 0.001) and dyslipidemia (36.7% vs 41.7%, p = 0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p < 0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p = 0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38–0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22–0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences.

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U2 - 10.1038/s41598-023-45345-3

DO - 10.1038/s41598-023-45345-3

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AN - SCOPUS:85174904005

SN - 2045-2322

VL - 13

JO - Scientific reports

JF - Scientific reports

IS - 1

M1 - 18375

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