Sex-specific HDL cholesterol changes with weight loss and their association with anthropometric variables: The LIFE study

Hiroshi Yatsuya, Robert W. Jeffery, Darin J. Erickson, Ericka M. Welsh, Andrew P. Flood, Melanie A. Jaeb, Patricia S. Laqua, Nathan R. Mitchell, Shelby L. Langer, Rona L. Levy

研究成果: ジャーナルへの寄稿学術論文査読

10 被引用数 (Scopus)

抄録

Decrease in the level of high-density lipoprotein cholesterol (HDLC) has been observed in women who start dieting, but not in men. Patterns of HDLC change during intentional weight loss through 30-months of follow-up, and their association with changes in anthropometric measurements were examined in obese women (N = 112) and men (N = 100). Missing HDLC values at 6-, 12-, 18-, and 30-month follow-up (N = 16, 34, 55, and 50, respectively) due to dropout were imputed by multiple imputation. Mean ages and BMIs of subjects at baseline were 47.2 years and 34.8kg/m 2 for women, and 50.4 years and 35.0kg/m 2 for men. On average, participants lost weight steadily for 12 months, followed by slow regain. During the first 6 months, HDLC decreased significantly in women (4.1mg/dl, P = 0.0007), but not in men. Significant HDLC increases were observed in both men and women from 6- to 12-month follow-up. HDLC changes in women were positively associated with changes in hip circumference from baseline to 12-month independent of changes in triglycerides (TG), glucose, and insulin. Rapid decrease of predominantly subcutaneous fat in the femoral and gluteal area might be associated with HDLC decrease in women during initial weight loss.

本文言語英語
ページ(範囲)429-435
ページ数7
ジャーナルObesity
19
2
DOI
出版ステータス出版済み - 02-2011

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学
  • 栄養および糖尿病

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