Shortened mean transit time in ct perfusion with singular value decomposition analysis in acute cerebral infarction: Quantitative evaluation and comparison with various ct perfusion parameters

Objective We aimed to clarify the cause of shortened mean transit time (MTT) in acute ischemic cerebrovascular disease and examined its relationship with reperfusion. Methods Twenty-three patients with acute ischemic cerebrovascular disease underwent whole-brain computed tomography perfusion (CTP). The maximum MTT (MTT max), minimum MTT (MTT min), ratio of maximum and minimum MTT (MTT min/max), and minimum cerebral blood volume (CBV) (CBV min) were measured by automatic region of interest analysis. Diffusion weighted image was performed to calculate infarction volume. We compared these CTP parameters between reperfusion and nonreperfusion groups and calculated correlation coefficients between the infarction core volume and CTP parameters. Results Significant differences were observed between reperfusion and nonreperfusion groups (MTT min/max: P = 0.014; CBV min ratio: P = 0.038). Regression analysis of CTP and high-intensity volume on diffusion weighted image showed negative correlation (CBV min ratio: r = -0.41; MTT min/max: r = -0.30; MTT min ratio: r = -0.27). Conclusions A region of shortened MTT indicated obstructed blood flow, which was attributed to the singular value decomposition method error.