Signal transduction in human embryo implantation

Michiko N. Fukuda, Kazuhiro Sugihara

研究成果: Review article査読

16 被引用数 (Scopus)

抄録

Determining the molecular mechanism of human embryo implantation is an extremely challenging task due to the limitation of materials and significant differences in this process among mammalian species. Trophinin has been identified as an apical cell adhesion molecule with potential involvement in human embryo implantation. We found that trophinin-mediated cell adhesion triggers signal transduction in human trophoblastic cells for proliferation and invasion, implicating in trophectoderm cell activation for placental formation. Prior to cell adhesion trophinin arrests ErbB4 by binding through bystin, which prevents ErbB4 from activation. Trophinin-mediated cell adhesion causes dissociation of bystin from trophinin, freeing ErbB4 from arrest and enabling tyrosine phosphorylation. Therefore trophinin functions as an adhesion molecule on the cell surface and as a molecular switch for trophoblast activation in the cytoplasm.

本文言語English
ページ(範囲)1153-1156
ページ数4
ジャーナルCell Cycle
6
10
DOI
出版ステータスPublished - 15-05-2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

フィンガープリント 「Signal transduction in human embryo implantation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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