Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury

Tomohiro Mizuno, Waichi Sato, Kazuhiro Ishikawa, Yuki Terao, Kazuo Takahashi, Yukihiro Noda, Yukio Yuzawa, Tadashi Nagamatsu

研究成果: Article

抄録

Background/aim: To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. Materials and methods: To detect changing expression of MATE1/SLC47A1 in dose- and time-dependent manners, human proximal tubular epithelial cells were incubated with AGE-aggregated-human serum albumin. As a function assay for MATE1/SLC47A1, human proximal tubular epithelial cells were incubated with cisplatin or carboplatin. Results: On incubation with AGEs, the expressions of MATE1/SLC47A1 were decreased in tubular cells. In addition, the toxicities of cisplatin were increased in tubular cells that had been pretreated with AGEs. However, the toxicities of carboplatin were smaller than that of cisplatin in proximal tubular epithelial cells. Conclusion: The expression of the MATE1/SLC47A1 is decreased by AGEs, which increases the risk for proximal tubular injury.

本文言語English
論文番号A198
ページ(範囲)1701-1706
ページ数6
ジャーナルOncoTargets and Therapy
8
DOI
出版ステータスPublished - 10-07-2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology (medical)

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