Smoking and colorectal cancer in a non-western population: A prospective cohort study in Japan

Kenji Wakai, Norihiko Hayakawa, Masayo Kojima, Koji Tamakoshi, Yoshiyuki Watanabe, Koji Suzuki, Shuji Hashimoto, Shinkan Tokudome, Hideaki Toyoshima, Yoshinori Ito, Akiko Tamakoshi

研究成果: Article

27 引用 (Scopus)

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BACKGROUND: The risk of colorectal cancer in relation to smoking habits has been examined mostly in Caucasians, and evidence for other ethnic groups is still scarce. METHODS: Our data came from the Japan Collaborative Cohort (JACC) Study. From 1988 through 1990, 25,260 men and 34,619 women aged 40-79 years completed a questionnaire on cigarette smoking and other lifestyle factors. Hazard ratios (HR) were estimated by fitting proportional hazards models. RESULTS: During the mean follow-up of 7.6 years through December 1997, we documented 408 incident colon cancers and 204 rectal cancers. We found a non-significant increase in colon cancer risk in male current smokers compared with never smokers. The multivariate-adjusted hazard ratios were 1.07 (95% confidence interval [Cl]: 0.72-1.59) for ex-smokers and 1.23 (95% Cl: 0.85-1.78) for current smokers. We however failed to observe a clear dose-response relationship between smoking intensity or duration and colon cancer risk. The adjusted hazard ratio was 1.07 (95% Cl: 0.71-1.61) even for 40+ years of smoking. Almost no increase in colon cancer risk was detected for female smokers, and male smokers were not at an enhanced risk of rectal cancer. CONCLUSIONS: Cigarette smoking was not a strong risk factor for colorectal cancer even after a long-term exposure, although a weak association remains open to discussion.

元の言語English
ページ(範囲)323-331
ページ数9
ジャーナルJournal of Epidemiology
13
発行部数6
出版物ステータスPublished - 01-11-2003

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All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Wakai, K., Hayakawa, N., Kojima, M., Tamakoshi, K., Watanabe, Y., Suzuki, K., Hashimoto, S., Tokudome, S., Toyoshima, H., Ito, Y., & Tamakoshi, A. (2003). Smoking and colorectal cancer in a non-western population: A prospective cohort study in Japan. Journal of Epidemiology, 13(6), 323-331.