Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers

Takahisa Kondo, Mutsuharu Hayashi, Kyosuke Takeshita, Yasushi Numaguchi, Koichi Kobayashi, Shigeo Iino, Yasuya Inden, Toyoaki Murohara

研究成果: Article査読

369 被引用数 (Scopus)

抄録

Objective - Circulating endothelial progenitor cells (EPCs) contribute to postnatal angiogenesis. The number of circulating EPCs has an inverse correlation with coronary risk scores. However, the effect of smoking on the number of circulating EPCs is not well-known. Methods and Results - We examined the effects of chronic smoking and of smoking cessation on EPC levels. Circulating EPCs were quantified by flow cytometry as CD45 lowCD34+CD133+ (progenitor cells [PCs]) or CD45lowCD34+CD133+VEGFR2+ (EPCs) in 14 nonsmokers and in 15 smokers. All smokers quit smoking. Eight quit smoking with nicotine patch and 7 without nicotine patch. PC/EPC levels were inversely correlated with the number of cigarettes smoked. Circulating PCs/EPCs increased rapidly after cessation (P<0.0001) and decreased again after resumption of smoking to the level similar to that before cessation (P=0.0031). The magnitude of increase in EPCs was greater in light smokers than in heavy smokers. Conclusions - The number of circulating PCs/EPCs was reduced in chronic smokers. Smoking cessation led to a rapid restoration of PC/EPC levels. The recovery of EPC levels was greater in light smokers than in heavy smokers. The decreased number of circulating EPCs would make smokers susceptible to cardiovascular disease, and even short-time cessation of smoking may be an effective means to reduce cardiovascular risk.

本文言語English
ページ(範囲)1442-1447
ページ数6
ジャーナルArteriosclerosis, thrombosis, and vascular biology
24
8
DOI
出版ステータスPublished - 08-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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