TY - JOUR
T1 - SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
AU - Unoki, Hiroyuki
AU - Takahashi, Atsushi
AU - Kawaguchi, Takahisa
AU - Hara, Kazuo
AU - Horikoshi, Momoko
AU - Andersen, Gitte
AU - Ng, Daniel P.K.
AU - Holmkvist, Johan
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Sandbæk, Annelli
AU - Lauritzen, Torsten
AU - Hansen, Torben
AU - Nurbaya, Siti
AU - Tsunoda, Tatsuhiko
AU - Kubo, Michiaki
AU - Babazono, Tetsuya
AU - Hirose, Hiroshi
AU - Hayashi, Matsuhiko
AU - Iwamoto, Yasuhiko
AU - Kashiwagi, Atsunori
AU - Kaku, Kohei
AU - Kawamori, Ryuzo
AU - Tai, E. Shyong
AU - Pedersen, Oluf
AU - Kamatani, Naoyuki
AU - Kadowaki, Takashi
AU - Kikkawa, Ryuichi
AU - Nakamura, Yusuke
AU - Maeda, Shiro
N1 - Funding Information:
We thank all participating doctors and staff from collaborating institutes for providing DNA samples. We also thank the technical staff of the Laboratory for Endocrinology and Metabolism at the Center for Genomic Medicine for providing technical assistance. This work was partly supported by a grant from the Leading Project of Ministry of Education, Culture, Sports, Science and Technology Japan. The Danish study was supported by Lundbeck Foundation Centre of Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care (LUCAMP), the European Union (EUGENE2, grant no. LSHM-CT-2004-512013) and the Danish Medical Research Council. Funding for Singapore arm of the study was supported by the National Medical Research Council (NMRC/1115/2007). We thank the staff of National Healthcare Group Polyclinics and National University of Singapore for their contributions towards the establishment of the Singapore Diabetes Cohort Study.
PY - 2008/9
Y1 - 2008/9
N2 - We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 × 10 -12; OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 × 10-9; OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 × 10-13; OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 × 10 -3; OR = 1.14, rs2237897, P = 2.4 × 10-4; OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 × 10 -11; OR = 1.24, rs2237897, P = 1.2 × 10-4; OR = 1.36).
AB - We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 × 10 -12; OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 × 10-9; OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 × 10-13; OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 × 10 -3; OR = 1.14, rs2237897, P = 2.4 × 10-4; OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 × 10 -11; OR = 1.24, rs2237897, P = 1.2 × 10-4; OR = 1.36).
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U2 - 10.1038/ng.208
DO - 10.1038/ng.208
M3 - Article
C2 - 18711366
AN - SCOPUS:50449085212
VL - 40
SP - 1098
EP - 1102
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 9
ER -