TY - JOUR
T1 - SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
AU - Unoki, Hiroyuki
AU - Takahashi, Atsushi
AU - Kawaguchi, Takahisa
AU - Hara, Kazuo
AU - Horikoshi, Momoko
AU - Andersen, Gitte
AU - Ng, Daniel P.K.
AU - Holmkvist, Johan
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Sandbæk, Annelli
AU - Lauritzen, Torsten
AU - Hansen, Torben
AU - Nurbaya, Siti
AU - Tsunoda, Tatsuhiko
AU - Kubo, Michiaki
AU - Babazono, Tetsuya
AU - Hirose, Hiroshi
AU - Hayashi, Matsuhiko
AU - Iwamoto, Yasuhiko
AU - Kashiwagi, Atsunori
AU - Kaku, Kohei
AU - Kawamori, Ryuzo
AU - Tai, E. Shyong
AU - Pedersen, Oluf
AU - Kamatani, Naoyuki
AU - Kadowaki, Takashi
AU - Kikkawa, Ryuichi
AU - Nakamura, Yusuke
AU - Maeda, Shiro
PY - 2008/9
Y1 - 2008/9
N2 - We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 × 10 -12; OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 × 10-9; OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 × 10-13; OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 × 10 -3; OR = 1.14, rs2237897, P = 2.4 × 10-4; OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 × 10 -11; OR = 1.24, rs2237897, P = 1.2 × 10-4; OR = 1.36).
AB - We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 × 10 -12; OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 × 10-9; OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 × 10-13; OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 × 10 -3; OR = 1.14, rs2237897, P = 2.4 × 10-4; OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 × 10 -11; OR = 1.24, rs2237897, P = 1.2 × 10-4; OR = 1.36).
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U2 - 10.1038/ng.208
DO - 10.1038/ng.208
M3 - Article
C2 - 18711366
AN - SCOPUS:50449085212
VL - 40
SP - 1098
EP - 1102
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 9
ER -