Sparse distribution of hepatocyte growth factor-producing cells inside hepatocellular foci in rats treated, with hepatocarcinogens

Toshio Imai, Masutaro Ichinose, Tokuma Yanai, Toshiaki Masegi, Toshikazu Nakamura, Tetsuya Tsukamoto, Kuniyoshi Kitoh, Masae Tatematsu

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The distribution of hepatocyte growth factor (HGF)-synthesizing cells in rat liver during development of glutathione S-transferase P form (GST-P)-positive nodules after diethylnitrosamine initiation followed by promotion with 2-acetylaminofluorene plus partial hepatectomy (PH) was investigated using in situ hybridization. HGF-producing cells were non-parenchymal in nature, and were suspected to be mainly of Kupffer type. They were mostly located outside GST-P-positive lesions, in the surrounding parenchyma. In the oval cell proliferation phase 1 week after PH, they increased and they were mainly localized around the portal triads. It is concluded that HGF is directly involved in an endogenous paracrine growth pathway controlling proliferation in oval cells and in normal, but not GST-P-positive, hepatocytes.

本文言語English
ページ(範囲)615-618
ページ数4
ジャーナルJapanese Journal of Cancer Research
88
7
DOI
出版ステータスPublished - 07-1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント 「Sparse distribution of hepatocyte growth factor-producing cells inside hepatocellular foci in rats treated, with hepatocarcinogens」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル