Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats

J. He, K. Yamada, L. B. Zou, T. Nabeshima

研究成果: Article

41 引用 (Scopus)

抜粋

We investigated the effects of okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, on spatial memory and neuronal survival in rats. Rats were initially trained on a spatial memory task in an eight arm radial maze. Spatial reference and working memory was impaired 1 day after the unilateral microinjection of OA into the dorsal hippocampus. The impairment was transient, and had disappeared by the following day. In contrast, neurodegeneration induced by OA was persistent and extended to the contralateral side 13 days after the injection. These results suggest that OA causes spatial memory impairment and neurodegeneration when injected directly into the hippocampus. Our findings also indicate dissociation between memory impairment and neurodegeneration induced by OA.

元の言語English
ページ(範囲)1435-1443
ページ数9
ジャーナルJournal of Neural Transmission
108
発行部数12
DOI
出版物ステータスPublished - 01-01-2001

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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