Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease

Lucian Hritcu, Alin Ciobica, Marius Stefan, Marius Mihasan, Lavinia Palamiuc, Toshitaka Nabeshima

研究成果: Article

31 引用 (Scopus)

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Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2μg/μl saline; 5μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS + 6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS + 6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.

元の言語English
ページ(範囲)35-43
ページ数9
ジャーナルNeuroscience Research
71
発行部数1
DOI
出版物ステータスPublished - 01-09-2011
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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