TY - JOUR
T1 - Spatial representations of self and other in the hippocampus
AU - Danjo, Teruko
AU - Toyoizumi, Taro
AU - Fujisawa, Shigeyoshi
N1 - Funding Information:
We thank A. Amarasingham for helpful suggestions on data analysis and T. J. McHugh and C. Yokoyama for comments on the manuscript. This work was supported by Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) nos. 16K14561 and 16H01290 to T.D. and 15H05876 and 16H01519 to S.F. All data necessary to support the paper’s conclusions are present in the paper and the supplementary materials.
PY - 2018/1/12
Y1 - 2018/1/12
N2 - An animal's awareness of its location in space depends on the activity of place cells in the hippocampus. How the brain encodes the spatial position of others has not yet been identified. We investigated neuronal representations of other animals' locations in the dorsal CA1 region of the hippocampus with an observational T-maze task in which one rat was required to observe another rat's trajectory to successfully retrieve a reward. Information reflecting the spatial location of both the self and the other was jointly and discretely encoded by CA1 pyramidal cells in the observer rat. A subset of CA1 pyramidal cells exhibited spatial receptive fields that were identical for the self and the other. These findings demonstrate that hippocampal spatial representations include dimensions for both self and nonself.
AB - An animal's awareness of its location in space depends on the activity of place cells in the hippocampus. How the brain encodes the spatial position of others has not yet been identified. We investigated neuronal representations of other animals' locations in the dorsal CA1 region of the hippocampus with an observational T-maze task in which one rat was required to observe another rat's trajectory to successfully retrieve a reward. Information reflecting the spatial location of both the self and the other was jointly and discretely encoded by CA1 pyramidal cells in the observer rat. A subset of CA1 pyramidal cells exhibited spatial receptive fields that were identical for the self and the other. These findings demonstrate that hippocampal spatial representations include dimensions for both self and nonself.
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U2 - 10.1126/science.aao3898
DO - 10.1126/science.aao3898
M3 - Article
C2 - 29326273
AN - SCOPUS:85040441108
SN - 0036-8075
VL - 359
SP - 213
EP - 218
JO - Science
JF - Science
IS - 6372
ER -