Sphingolipids involved in the induction of multinuclear cell formation

Yasunori Kozutsumi, Takayuki Kanazawa, Yidi Sun, Toshiyuki Yamaji, Harumi Yamamoto, Hiromu Takematsu

研究成果: Review article査読

30 被引用数 (Scopus)


In this review, we focus on sphingolipids as potential regulators of the induction of multinuclear cell formation through the inhibition of cytokinesis. A sphingolipid, psychosine (Psy) (galactosylsphingosine), was demonstrated to be a trigger lipid for the inhibition of cytokinesis and the induction of multinuclear giant cells associated with a sphingolipid metabolic disease, globoid cell leukodystrophy (GLD). Indeed, Psy is known to accumulate in the patients' brains. Interestingly, inhibition of sphingolipid biosynthesis also induced multinuclear cells. When cells were treated with a new immunosuppressant, ISP-1/myriocin, which inhibits serine palmitoyltransferase, the first step enzyme of sphingolipid biosynthesis, the cells underwent multinucleation and apoptosis. At present, a definitive model of the function of sphingolipids as to the induction of multinuclear cell formation is not available due to the rudimentary information but possible mechanisms are discussed.

ジャーナルBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
出版ステータスPublished - 23-05-2002

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

フィンガープリント 「Sphingolipids involved in the induction of multinuclear cell formation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。