Staurosporine, a protein kinase inhibitor, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit

Toshitaka Nabeshima, Shin ichi Ogawa, Hidenao Nishimura, Kazuyuki Fuji, Tsutomu Kameyama, Yasuharu Sasaki

研究成果: Article査読

11 被引用数 (Scopus)

抄録

We have investigated whether administration of staurosporine, which has been reported to induce differentiation in the human neuroblastoma cell in vitro, attenuates amnesia induced by basal forebrain lesion in rats. Multiple dosage of staurosporine at the doses of 0.05 and 0.1 mg/kg (i.p.) attenuated the impaired performance of the water maze task. Moreover, staurosporine (0.1 mg/kg) reversed the decrease of choline acetyltransferase activity in the fronto-parietal cortex. These results suggest that staurosporine attenuates amnesia through reversal of deficits in cholinergic neurons induced by basal forebrain lesion, and that neurotrophic factor-like substances may open the way for novel therapeutic approaches to Alzheimer's disease.

本文言語English
ページ(範囲)13-16
ページ数4
ジャーナルNeuroscience Letters
122
1
DOI
出版ステータスPublished - 14-01-1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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