Stimulation-dependent intraspinal microtubules and synaptic failure in Alzheimer's disease: A review

Fuyuki Mitsuyama, Yoshio Futatsugi, Masato Okuya, Tsukasa Kawase, Kostadin Karagiozov, Yoko Kato, Tetsuo Kanno, Hirotoshi Sano, Shizuko Nagao, Tadashi Koide

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

There are many microtubules in axons and dendritic shafts, but it has been thought that there were fewer microtubules in spines. Recently, there have been four reports that observed the intraspinal microtubules. Because microtubules originate from the centrosome, these four reports strongly suggest a stimulation-dependent connection between the nucleus and the stimulated postsynaptic membrane by microtubules. In contrast, several pieces of evidence suggest that spine elongation may be caused by the polymerization of intraspinal microtubules. This structural mechanism for spine elongation suggests, conversely, that the synapse loss or spine loss observed in Alzheimer's disease may be caused by the depolymerization of intraspinal microtubules. Based on this evidence, it is suggested that the impairment of intraspinal microtubules may cause spinal structural change and block the translocation of plasticity-related molecules between the stimulated postsynaptic membranes and the nucleus, resulting in the cognitive deficits of Alzheimer's disease.

本文言語English
論文番号519682
ジャーナルInternational Journal of Alzheimer's Disease
DOI
出版ステータスPublished - 2012

All Science Journal Classification (ASJC) codes

  • 加齢科学
  • 神経学
  • 臨床神経学
  • 認知神経科学
  • 細胞および分子神経科学
  • 行動神経科学

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