Stroma biglycan expression can be a prognostic factor in prostate cancers

Jun Furumido, Nako Maishi, Aya Yanagawa-Matsuda, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoshihiro Matsuno, Nobuo Shinohara, Yasuhiro Hida, Kyoko Hida

研究成果: ジャーナルへの寄稿学術論文査読

2 被引用数 (Scopus)

抄録

Objectives: This study analyzes the relationship between biglycan expression in prostate cancer and clinicopathological parameters to clarify the potential link between biglycan and prognosis and progression to castration-resistant prostate cancer (CRPC). Methods: We retrospectively analyzed 60 cases of prostate cancer patients who underwent robot-assisted laparoscopic radical prostatectomy in Hokkaido University Hospital. Results: Biglycan was expressed in the tumor stroma but not in tumor cells. There was no significant relationship with biochemical recurrence (p = 0.5237), but the expression of biglycan was 36.1% in the group with progression to CRPC. This indicates a significant relationship with progression to CRPC (p = 0.0182). Furthermore, the expression of biglycan-positive blood vessels was significantly higher (15.9%) in the group with biochemical recurrence than in the group without biochemical recurrence (8.5%) (p = 0.0169). The biglycan-positive vessels were 28.6% in the group with progression to CRPC, which was significantly higher than that in the group without progression to CRPC (p < 0.0001). Conclusion: This is the first study to show that stroma biglycan is a useful prognostic factor for prostate cancer.

本文言語英語
ページ(範囲)147-154
ページ数8
ジャーナルInternational Journal of Urology
30
2
DOI
出版ステータス出版済み - 02-2023

All Science Journal Classification (ASJC) codes

  • 泌尿器学

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