Structure and function of snake venom proteins affecting platelet plug formation

Taei Matsui, Jiharu Hamako, Koiti Titani

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

Many snake venom proteins have been isolated that affect platelet plug formation by interacting either with platelet integrins, membrane glycoprotein Ib (GPIb), or plasma von Willebrand factor (VWF). Among them, disintegrins purified from various snake venoms are strong inhibitors of platelet aggregation. Botrocetin and bitiscetin derived from Bothrops jararaca and Bitis arietans venom, respectively, induce VWF-dependent platelet agglutination in vitro. Several GPIb-binding proteins have also been isolated from snake venoms. In this review, we focus on the structure and function of those snake venom proteins that influence platelet plug formation. These proteins are potentially useful as reagents for the sub-diagnosis of platelet disorder or von Willebrand disease, as well as for clinical and basic research of thrombosis and hemostasis.

本文言語English
ページ(範囲)10-23
ページ数14
ジャーナルToxins
2
1
DOI
出版ステータスPublished - 01-2010

All Science Journal Classification (ASJC) codes

  • 毒物学
  • 健康、毒物学および変異誘発

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