Structure of Acrosome Reaction-Inducing Steroidal Saponins from the Egg Jelly of the Starfish, Asterias amurensis

Yoshinori Fujimoto, Taketoshi Yamada, Nobuo Ikekawa, Taei Matsui, Ichiro Nishiyama, Motonori Hoshi

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Three steroidal saponins (designated as Co-ARIS I, II, III) which are essential for inducing the acrosome reaction, were isolated from the egg jelly of the starfish, Asterias amurensis, and their structures were elucidated by chemical and spectral means. The structure of Co-ARIS II was determined to be 6α-O-{O-β-D-fucopyranosyl-(1→2)-O-β-D-fucopyranosyl-(l→ 4)-[O-β-d-quinovopyranosyl-(1→ 2)]-O-β-D-quinovopyranosyl-(l→3)-6-deoxy-β-D-xylo-hexos-4-ulopyranos-l-yl}-3β-hydroxysulfonyloxy-5α-cholesta-9(l 1), 17(20),24-trien-23-one (2), whereas Co-ARIS I (1) and Co-ARIS III (3) were identical with ovarian asterosaponin-1 (OA-1) and OA-4 previously isolated from the same species of starfish.

本文言語English
ページ(範囲)1829-1832
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
35
5
DOI
出版ステータスPublished - 1987
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

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