Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line

Yumi Nishiyama, Yuki Noda, Noriyoshi Nakatani, Nobukazu Shitan, Tamotsu Sudo, Atsushi Kato, Patrick B. Chalo Mutiso

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

Three aromatic compounds, 2α,3α-epoxyflavan-5,7,4′-triol-(4β → 8)-afzelechin (1), 2β,3β-epoxyflavan-5,7,4′-triol-(4α → 8)-epiafzelechin (2), and methyl 4-ethoxy-2-hydroxy-6-propylbenzoate (3), as well as eight known compounds (4–11) were isolated from the bark of Cassipourea malosana (Rhizophoraceae). Their structures were determined on the basis of an analysis of spectroscopic data. The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated. Most compounds showed little activity; however, the methyl derivatives of flavan dimers (1a and 2a) showed higher activity (IC 50 value of 30.3 and 75.4 μM) than parent compounds 1 and 2.

本文言語英語
ページ(範囲)289-296
ページ数8
ジャーナルJournal of Natural Medicines
73
1
DOI
出版ステータス出版済み - 25-01-2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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