Subtle myocardial damage associated with diagnostic coronary angiography alone

Hisashi Umeda, Tomoyuki Ota, Mitsunori Iwase, Hideo Izawa, Shinjiro Miyata, Shigeo Sugino, Kazutaka Hayashi, Naoki Misumida, Yasushi Takeichi, Ryoji Ishiki, Haruo Inagaki, Toyoaki Murohara

研究成果: Article査読

2 被引用数 (Scopus)


Aims: To evaluate the frequency, predictors and prognostic significance of elevation in cardiac troponin I (cTnI) after coronary angiography (CAG). Methods and results: A series of 296 consecutive patients with normal pre-procedural cTnI levels and undergoing elective CAG at our centre were prospectively analysed. Positive cTnI elevation was defined as >0.06 ng/ml. Positive cTnI elevation was observed in 44 patients (14.8%), but CK-MB was elevated in only four patients (1.3%) after the procedure. The risk of cTnI elevation was independently associated with left ventricular hypertrophy (odds ratio [OR] 5.52; 95% confidence interval [CI], 2.54 to 12.02; P<0.001), inexperienced operator (OR 10.83; 95% CI, 2.47 to 47.43; P=0.002) and the amount of contrast agent (OR 1.12; 95% CI, 1.03 to 1.23; P=0.009 for each 10 ml increase), whereas it was not associated with the severity of coronary artery disease. At one year, however, postprocedural elevation of cTnI was not associated with an increased risk of death (2.3% vs. 0.8%, P=0.384) or myocardial infarction (2.3% vs. 2.0%, P=0.623). Conclusions: A minor elevation of cTnI is observed commonly after CAG, which might be associated with left ventricular hypertrophy, operator's experience and the amount of contrast used; however, it does not influence 1-year events rates.

出版ステータスPublished - 08-2010

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学


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