Subventricular zone under the neuroinflammatory stress and Parkinson's disease

Keiji Mori, Yoko S. Kaneko, Akira Nakashima, Hiroshi Nagasaki, Toshiharu Nagatsu, Ikuko Nagatsu, Akira Ota

研究成果: Review article査読

4 被引用数 (Scopus)


This review summarizes the effects of neuroinflammatory stress on the subventricular zone (SVZ), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with Parkinson's disease (PD), because the SVZ is under the control of dopaminergic afferents from the substantia nigra (SN). In Lewy bodies-positive-PD, microglia is known to phagocytoze aggregated α-synuclein, resulting in the release of inflammatory cytokines. The neurogenesis in the SVZ should be affected in PD brain by the neuroinflammatory process. The administration of lipopolysaccaharide is available as an alternative model for microglia-induced loss of dopaminergic neurons and also the impairment of stem cell maintenance. Therefore, the research on the neuroinflammatory process in the SVZ gives us a hint to prevent the outbreak of PD or at least slow the disease process.

ジャーナルCellular and molecular neurobiology
出版ステータスPublished - 01-07-2012

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 細胞生物学


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