Summation of initiation activities in the liver after partial hepatectomy

Hiroki Sakai, Tetsuya Tsukamoto, Masami Yamamoto, Akihiro Hirata, Atsushi Inagami, Norimitsu Shirai, Takeshi Iidaka, Tokuma Yanai, Toshiaki Masegi, Masae Tatematsu

研究成果: ジャーナルへの寄稿学術論文査読

11 被引用数 (Scopus)


Summation of initiation activities of different carcinogens in the liver after partial hepatectomy (PH) was investigated with reference to induction of glutathione S-transeferase placental form (GST-P) positive foci. Firstly, effects of repeated administration of 1,2-dimethylhydradine (DMH) were compared with the results of a single administration of the same total dose (Expt. I). Subsequently, we studied summation of initiation potential with serial administration of DMH with diethylnitrosamine (DEN) or N-bis (2-hydroxpropyl)-nitrosamine (DHPN). In Expt. I, induction of GST-P-positive foci by multiple low-dose administration was equal to that with the single large-dose treatment. In order to avoid toxicity in hepatectomized rats, the low repeated-dose approach appeared superior. In Expt. II, the numbers of GST-P-positive foci in the groups treated with DMH plus DHPN or DMH plus DEN were significantly higher than those in the groups receiving the carcinogens singly. It is concluded that there is summation of initiation potential with doses of a single or multiple carcinogens. These results suggest that the present initiation assay model is useful to investigate summation of initiation activities of various environmental chemicals.

ジャーナルCancer Letters
出版ステータス出版済み - 08-02-2002

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究


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