抄録
Formation of senile plaques composed of amyloid β peptide, a pathological hallmark of Alzheimer disease, in human brains precedes disease onset by many years. Noninvasive detection of such plaques could be critical in presymptomatic diagnosis and could contribute to early preventive treatment strategies. Using amyloid precursor protein (APP) transgenic mice as a model of amyloid β amyloidosis, we demonstrate here that an intravenously administered 19F-containing amyloidophilic compound labels brain plaques and allows them to be visualized in living mice by magnetic resonance imaging (MRI) using 19F and 1H. Our findings provide a new direction for specific noninvasive amyloid imaging without the danger of exposure to radiation. This approach could be used in longitudinal studies in mouse models of Alzheimer disease to search for biomarkers associated with amyloid β pathology as well as to track disease course after treatment with candidate medications.
本文言語 | 英語 |
---|---|
ページ(範囲) | 527-533 |
ページ数 | 7 |
ジャーナル | Nature Neuroscience |
巻 | 8 |
号 | 4 |
DOI | |
出版ステータス | 出版済み - 04-2005 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 神経科学一般