19F and 1H MRI detection of amyloid β plaques in vivo

Makoto Higuchi, Nobuhisa Iwata, Yukio Matsuba, Kumi Sato, Kazumi Sasamoto, Takaomi C. Saido

研究成果: ジャーナルへの寄稿学術論文査読

342 被引用数 (Scopus)

抄録

Formation of senile plaques composed of amyloid β peptide, a pathological hallmark of Alzheimer disease, in human brains precedes disease onset by many years. Noninvasive detection of such plaques could be critical in presymptomatic diagnosis and could contribute to early preventive treatment strategies. Using amyloid precursor protein (APP) transgenic mice as a model of amyloid β amyloidosis, we demonstrate here that an intravenously administered 19F-containing amyloidophilic compound labels brain plaques and allows them to be visualized in living mice by magnetic resonance imaging (MRI) using 19F and 1H. Our findings provide a new direction for specific noninvasive amyloid imaging without the danger of exposure to radiation. This approach could be used in longitudinal studies in mouse models of Alzheimer disease to search for biomarkers associated with amyloid β pathology as well as to track disease course after treatment with candidate medications.

本文言語英語
ページ(範囲)527-533
ページ数7
ジャーナルNature Neuroscience
8
4
DOI
出版ステータス出版済み - 04-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般

フィンガープリント

19F and 1H MRI detection of amyloid β plaques in vivo」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル