89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases

Seiichiro Ota, Masaki Uno, Masaki Kato, Masanobu Ishiguro, Takahiro Natsume, Kaoru Kikukawa, Masanori Tadokoro, Takashi Ichihara, Hiroshi Toyama

研究成果: Article

2 引用 (Scopus)

抄録

Objective: Strontium-89 chloride (89Sr) bremsstrahlung single photon emission computed tomography (SPECT) imaging was evaluated for detecting more detailed whole body 89Sr distribution. Methods: 89Sr bremsstrahlung whole body planar and merged SPECT images were acquired using two-detector SPECT system. Energy window A (100 keV ± 50 %) for planar imaging and energy window A plus adjacent energy window B (300 keV ± 50 %) for SPECT imaging were set on the continuous spectrum. Thirteen patients with multiple bone metastases were evaluated. Bone metastases can be detected with 99mTc-HMDP whole body planar and merged SPECT images and compared with 89Sr bremsstrahlung whole body planar and merged SPECT images. Based on the location of metastatic lesions seen as hot spots on 99mTc-HMDP images as a reference, the hot spots on 89Sr bremsstrahlung images were divided into the same bone parts as 99mTc-HMDP images (a total of 35 parts in the whole body), and the number of hot spots were counted. We also evaluated the incidence of extra-osseous uptakes in the intestine on 89Sr bremsstrahlung whole body planar images. Results: A total of 195 bone metastatic lesions were detected in both 99mTc-HMDP whole body planar and merged SPECT images. Detection of hot spot lesions in 89Sr merged SPECT images (127 of 195; 66 %) was more frequent than in 89Sr whole body planar images (108 of 195; 56 %), based on metastatic bone lesions in 99mTc-HMDP whole body planar and merged SPECT images. A large intestinal 89Sr accumulation was detected in 5 of the 13 patients (38 %). Conclusions: 89Sr bremsstrahlung-merged SPECT imaging could be more useful for detailed detection of whole body 89Sr distribution than planar imaging. Intestinal 89Sr accumulation due to 89Sr physiologic excretion was detected in feces for 4 days after tracer injection.

元の言語English
ページ(範囲)112-119
ページ数8
ジャーナルAnnals of Nuclear Medicine
28
発行部数2
DOI
出版物ステータスPublished - 01-02-2014

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Gamma Cameras
Single-Photon Emission-Computed Tomography
Neoplasm Metastasis
Bone and Bones
Body Image
Feces
Intestines
Injections

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

Ota, Seiichiro ; Uno, Masaki ; Kato, Masaki ; Ishiguro, Masanobu ; Natsume, Takahiro ; Kikukawa, Kaoru ; Tadokoro, Masanori ; Ichihara, Takashi ; Toyama, Hiroshi. / 89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases. :: Annals of Nuclear Medicine. 2014 ; 巻 28, 番号 2. pp. 112-119.
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title = "89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases",
abstract = "Objective: Strontium-89 chloride (89Sr) bremsstrahlung single photon emission computed tomography (SPECT) imaging was evaluated for detecting more detailed whole body 89Sr distribution. Methods: 89Sr bremsstrahlung whole body planar and merged SPECT images were acquired using two-detector SPECT system. Energy window A (100 keV ± 50 {\%}) for planar imaging and energy window A plus adjacent energy window B (300 keV ± 50 {\%}) for SPECT imaging were set on the continuous spectrum. Thirteen patients with multiple bone metastases were evaluated. Bone metastases can be detected with 99mTc-HMDP whole body planar and merged SPECT images and compared with 89Sr bremsstrahlung whole body planar and merged SPECT images. Based on the location of metastatic lesions seen as hot spots on 99mTc-HMDP images as a reference, the hot spots on 89Sr bremsstrahlung images were divided into the same bone parts as 99mTc-HMDP images (a total of 35 parts in the whole body), and the number of hot spots were counted. We also evaluated the incidence of extra-osseous uptakes in the intestine on 89Sr bremsstrahlung whole body planar images. Results: A total of 195 bone metastatic lesions were detected in both 99mTc-HMDP whole body planar and merged SPECT images. Detection of hot spot lesions in 89Sr merged SPECT images (127 of 195; 66 {\%}) was more frequent than in 89Sr whole body planar images (108 of 195; 56 {\%}), based on metastatic bone lesions in 99mTc-HMDP whole body planar and merged SPECT images. A large intestinal 89Sr accumulation was detected in 5 of the 13 patients (38 {\%}). Conclusions: 89Sr bremsstrahlung-merged SPECT imaging could be more useful for detailed detection of whole body 89Sr distribution than planar imaging. Intestinal 89Sr accumulation due to 89Sr physiologic excretion was detected in feces for 4 days after tracer injection.",
author = "Seiichiro Ota and Masaki Uno and Masaki Kato and Masanobu Ishiguro and Takahiro Natsume and Kaoru Kikukawa and Masanori Tadokoro and Takashi Ichihara and Hiroshi Toyama",
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month = "2",
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doi = "10.1007/s12149-013-0788-3",
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Ota, S, Uno, M, Kato, M, Ishiguro, M, Natsume, T, Kikukawa, K, Tadokoro, M, Ichihara, T & Toyama, H 2014, '89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases', Annals of Nuclear Medicine, 巻. 28, 番号 2, pp. 112-119. https://doi.org/10.1007/s12149-013-0788-3

89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases. / Ota, Seiichiro; Uno, Masaki; Kato, Masaki; Ishiguro, Masanobu; Natsume, Takahiro; Kikukawa, Kaoru; Tadokoro, Masanori; Ichihara, Takashi; Toyama, Hiroshi.

:: Annals of Nuclear Medicine, 巻 28, 番号 2, 01.02.2014, p. 112-119.

研究成果: Article

TY - JOUR

T1 - 89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases

AU - Ota, Seiichiro

AU - Uno, Masaki

AU - Kato, Masaki

AU - Ishiguro, Masanobu

AU - Natsume, Takahiro

AU - Kikukawa, Kaoru

AU - Tadokoro, Masanori

AU - Ichihara, Takashi

AU - Toyama, Hiroshi

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Objective: Strontium-89 chloride (89Sr) bremsstrahlung single photon emission computed tomography (SPECT) imaging was evaluated for detecting more detailed whole body 89Sr distribution. Methods: 89Sr bremsstrahlung whole body planar and merged SPECT images were acquired using two-detector SPECT system. Energy window A (100 keV ± 50 %) for planar imaging and energy window A plus adjacent energy window B (300 keV ± 50 %) for SPECT imaging were set on the continuous spectrum. Thirteen patients with multiple bone metastases were evaluated. Bone metastases can be detected with 99mTc-HMDP whole body planar and merged SPECT images and compared with 89Sr bremsstrahlung whole body planar and merged SPECT images. Based on the location of metastatic lesions seen as hot spots on 99mTc-HMDP images as a reference, the hot spots on 89Sr bremsstrahlung images were divided into the same bone parts as 99mTc-HMDP images (a total of 35 parts in the whole body), and the number of hot spots were counted. We also evaluated the incidence of extra-osseous uptakes in the intestine on 89Sr bremsstrahlung whole body planar images. Results: A total of 195 bone metastatic lesions were detected in both 99mTc-HMDP whole body planar and merged SPECT images. Detection of hot spot lesions in 89Sr merged SPECT images (127 of 195; 66 %) was more frequent than in 89Sr whole body planar images (108 of 195; 56 %), based on metastatic bone lesions in 99mTc-HMDP whole body planar and merged SPECT images. A large intestinal 89Sr accumulation was detected in 5 of the 13 patients (38 %). Conclusions: 89Sr bremsstrahlung-merged SPECT imaging could be more useful for detailed detection of whole body 89Sr distribution than planar imaging. Intestinal 89Sr accumulation due to 89Sr physiologic excretion was detected in feces for 4 days after tracer injection.

AB - Objective: Strontium-89 chloride (89Sr) bremsstrahlung single photon emission computed tomography (SPECT) imaging was evaluated for detecting more detailed whole body 89Sr distribution. Methods: 89Sr bremsstrahlung whole body planar and merged SPECT images were acquired using two-detector SPECT system. Energy window A (100 keV ± 50 %) for planar imaging and energy window A plus adjacent energy window B (300 keV ± 50 %) for SPECT imaging were set on the continuous spectrum. Thirteen patients with multiple bone metastases were evaluated. Bone metastases can be detected with 99mTc-HMDP whole body planar and merged SPECT images and compared with 89Sr bremsstrahlung whole body planar and merged SPECT images. Based on the location of metastatic lesions seen as hot spots on 99mTc-HMDP images as a reference, the hot spots on 89Sr bremsstrahlung images were divided into the same bone parts as 99mTc-HMDP images (a total of 35 parts in the whole body), and the number of hot spots were counted. We also evaluated the incidence of extra-osseous uptakes in the intestine on 89Sr bremsstrahlung whole body planar images. Results: A total of 195 bone metastatic lesions were detected in both 99mTc-HMDP whole body planar and merged SPECT images. Detection of hot spot lesions in 89Sr merged SPECT images (127 of 195; 66 %) was more frequent than in 89Sr whole body planar images (108 of 195; 56 %), based on metastatic bone lesions in 99mTc-HMDP whole body planar and merged SPECT images. A large intestinal 89Sr accumulation was detected in 5 of the 13 patients (38 %). Conclusions: 89Sr bremsstrahlung-merged SPECT imaging could be more useful for detailed detection of whole body 89Sr distribution than planar imaging. Intestinal 89Sr accumulation due to 89Sr physiologic excretion was detected in feces for 4 days after tracer injection.

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