Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus

Kazushige Mizoguchi, Hirotaka Shoji, Ryuji Ikeda, Yayoi Tanaka, Wakako Maruyama, Takeshi Tabira

研究成果: Article査読

8 被引用数 (Scopus)

抄録

We previously demonstrated that suppression of glucocorticoid secretion by adrenalectomy (ADX) impaired prefrontal cortex-sensitive working memory, but not reference memory. Since the cholinergic system in the hippocampus is also involved in these memories, we examined the effects of glucocorticoid suppression on cholinergic transmission in the rat hippocampus. A microdialysis study revealed that ADX did not affect the basal acetylcholine release, but enhanced the KCl-evoked response. This enhanced response was reversed by the corticosterone replacement treatment. The extracellular choline concentrations increased under both basal and KCl-stimulated conditions in the ADX rats, and these increases were also reversed by the corticosterone replacement. These results indicate that suppression of glucocorticoid secretion enhances cholinergic transmission in the hippocampus in response to stimuli. It is possible that this enhanced cholinergic transmission may not contribute to the ADX-induced working memory impairment, but it may be involved in maintenance of reference memory.

本文言語English
ページ(範囲)612-615
ページ数4
ジャーナルBrain Research Bulletin
76
6
DOI
出版ステータスPublished - 15-08-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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