TY - JOUR
T1 - Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus
AU - Mizoguchi, Kazushige
AU - Shoji, Hirotaka
AU - Ikeda, Ryuji
AU - Tanaka, Yayoi
AU - Maruyama, Wakako
AU - Tabira, Takeshi
N1 - Funding Information:
This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (18590663), the Research Grant for Longevity Sciences (18C-8) from the Ministry of Health, Labor and Welfare of Japan, and the Japan Health Foundation for the Prevention of Chronic Diseases and the Improvement of QOL of Patients.
PY - 2008/8/15
Y1 - 2008/8/15
N2 - We previously demonstrated that suppression of glucocorticoid secretion by adrenalectomy (ADX) impaired prefrontal cortex-sensitive working memory, but not reference memory. Since the cholinergic system in the hippocampus is also involved in these memories, we examined the effects of glucocorticoid suppression on cholinergic transmission in the rat hippocampus. A microdialysis study revealed that ADX did not affect the basal acetylcholine release, but enhanced the KCl-evoked response. This enhanced response was reversed by the corticosterone replacement treatment. The extracellular choline concentrations increased under both basal and KCl-stimulated conditions in the ADX rats, and these increases were also reversed by the corticosterone replacement. These results indicate that suppression of glucocorticoid secretion enhances cholinergic transmission in the hippocampus in response to stimuli. It is possible that this enhanced cholinergic transmission may not contribute to the ADX-induced working memory impairment, but it may be involved in maintenance of reference memory.
AB - We previously demonstrated that suppression of glucocorticoid secretion by adrenalectomy (ADX) impaired prefrontal cortex-sensitive working memory, but not reference memory. Since the cholinergic system in the hippocampus is also involved in these memories, we examined the effects of glucocorticoid suppression on cholinergic transmission in the rat hippocampus. A microdialysis study revealed that ADX did not affect the basal acetylcholine release, but enhanced the KCl-evoked response. This enhanced response was reversed by the corticosterone replacement treatment. The extracellular choline concentrations increased under both basal and KCl-stimulated conditions in the ADX rats, and these increases were also reversed by the corticosterone replacement. These results indicate that suppression of glucocorticoid secretion enhances cholinergic transmission in the hippocampus in response to stimuli. It is possible that this enhanced cholinergic transmission may not contribute to the ADX-induced working memory impairment, but it may be involved in maintenance of reference memory.
UR - https://www.scopus.com/pages/publications/45849138491
UR - https://www.scopus.com/pages/publications/45849138491#tab=citedBy
U2 - 10.1016/j.brainresbull.2008.03.003
DO - 10.1016/j.brainresbull.2008.03.003
M3 - Article
C2 - 18598852
AN - SCOPUS:45849138491
SN - 0361-9230
VL - 76
SP - 612
EP - 615
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 6
ER -