Suppression of hepatitis C virus replicon by TGF-β

Takayuki Murata, Takayuki Ohshima, Masashi Yamaji, Masahiro Hosaka, Yusuke Miyanari, Makoto Hijikata, Kunitada Shimotohno

研究成果: Article

51 引用 (Scopus)

抄録

Hepatitis C virus (HCV) is one of the major causative agents of liver diseases, such as liver inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. Using an efficient HCV subgenomic replicon system, we demonstrate that transforming growth factor-beta (TGF-β) suppresses viral RNA replication and protein expression from the HCV replicon. We further show that the anti-viral effect of this cytokine is associated with cellular growth arrest in a manner dependent on Smad signaling, not mitogen-activated protein kinase (MAPK) signaling. These results suggest a novel insight into the mechanisms of liver diseases caused by HCV.

元の言語English
ページ(範囲)407-417
ページ数11
ジャーナルVirology
331
発行部数2
DOI
出版物ステータスPublished - 20-01-2005

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Replicon
Hepacivirus
Transforming Growth Factor beta
Liver Diseases
Viral RNA
Viral Proteins
Mitogen-Activated Protein Kinases
Liver Cirrhosis
Hepatocellular Carcinoma
Fibrosis
Cytokines
Inflammation
Growth

All Science Journal Classification (ASJC) codes

  • Virology

これを引用

Murata, T., Ohshima, T., Yamaji, M., Hosaka, M., Miyanari, Y., Hijikata, M., & Shimotohno, K. (2005). Suppression of hepatitis C virus replicon by TGF-β. Virology, 331(2), 407-417. https://doi.org/10.1016/j.virol.2004.10.036
Murata, Takayuki ; Ohshima, Takayuki ; Yamaji, Masashi ; Hosaka, Masahiro ; Miyanari, Yusuke ; Hijikata, Makoto ; Shimotohno, Kunitada. / Suppression of hepatitis C virus replicon by TGF-β. :: Virology. 2005 ; 巻 331, 番号 2. pp. 407-417.
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Murata, T, Ohshima, T, Yamaji, M, Hosaka, M, Miyanari, Y, Hijikata, M & Shimotohno, K 2005, 'Suppression of hepatitis C virus replicon by TGF-β', Virology, 巻. 331, 番号 2, pp. 407-417. https://doi.org/10.1016/j.virol.2004.10.036

Suppression of hepatitis C virus replicon by TGF-β. / Murata, Takayuki; Ohshima, Takayuki; Yamaji, Masashi; Hosaka, Masahiro; Miyanari, Yusuke; Hijikata, Makoto; Shimotohno, Kunitada.

:: Virology, 巻 331, 番号 2, 20.01.2005, p. 407-417.

研究成果: Article

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Murata T, Ohshima T, Yamaji M, Hosaka M, Miyanari Y, Hijikata M その他. Suppression of hepatitis C virus replicon by TGF-β. Virology. 2005 1 20;331(2):407-417. https://doi.org/10.1016/j.virol.2004.10.036