Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2α

Seiji Sumigama, Tomomi Ito, Hiroaki Kajiyama, Kiyosumi Shibata, Koji Tamakoshi, Fumitaka Kikkawa, Trevor Williams, Michael A. Tainsky, Seiji Nomura, Shigehiko Mizutani

研究成果: Article

24 被引用数 (Scopus)

抄録

A previous report demonstrated that AP-2α favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2α in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2α in SKOV3 human ovarian cancer cells, which originally possess little AP-2α. AP-2α overexpression changed cell morphology from spindle to epithelioid type and suppressed cell proliferation and invasion, which would be partially correlated with decreased phosphorylation levels of the erbB2, Akt and ERK pathways, increased E-cadherin and reduced pro-matrix metalloproteinase-2 levels. Moreover, nude mice intraperitoneally injected with AP-2α-overexpressing cells survived longer than those with neotransfected cells. The present data represent the first direct evidence that AP-2α plays a tumor suppressive role in ovarian cancer.

本文言語English
ページ(範囲)5496-5504
ページ数9
ジャーナルOncogene
23
32
DOI
出版ステータスPublished - 15-07-2004

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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