Suppressive effects of fruit-juice concentrate of prunus mume sieb. et zucc. (Japanese apricot, Ume) on helicobacter pyloriinduced glandular stomach lesions in Mongolian gerbils

Takafumi Otsuka, Tetsuya Tsukamoto, Harunari Tanaka, Kenichi Inada, Hirotoshi Utsunomiya, Tsutomu Mizoshita, Toshiko Kumagai, Tsutomu Katsuyama, Kazumasa Miki, Masae Tatematsu

研究成果: Review article査読

34 被引用数 (Scopus)

抄録

Helicobacter pylori (Hp) infection is an important factor in human gastric disorders, including chronic active gastritis, peptic ulcers, intestinal metaplasia and cancer. Since epidemiologic studies overwhelmingly agree on a protective influence of fruits and vegetables in reducing the risk of gastric neoplasia and processed foods made from Prunus mume Sieb. et Zucc. (Japanese apricot or "Ume" in Japanese) are traditionally known for their miscellaneous medical effects, in the present study we investigated the efficacy of a fruit-juice concentrate of Japanese apricot (CJA) in the glandular stomach of Hp-infected Mongolian gerbils. Hp-inoculated gerbils were given CJA in their drinking water at concentrations of 1 and 3% for 10 weeks. The microscopic scores for gastritis and mucosal hyperplasia in the CJA groups were significantly lower than in the Hp-inoculated control group, with dose-dependence. Real-time PCR was performed to quantitate Hp by demonstrating urease A gene amount using gerbils' glyceraldehyde-3-phophate dehydrogenase (GAPDH) gene as an internal control. Average relative urease A gene dosage in the glandular stomach in the 1 and 3% CJA and Hp-inoculated control groups was 26.6 ± 11.6% (average ± SE), 30.3 ± 10.5%, 100 ± 40.9%, respectively, the fruit-juice concentrate causing significant lowering (P<0.01 and P<0.05, respectively, with 1 and 3%). These findings suggest that suppressive effects on gastric cancer development might also be expected as a result of decreased numbers of Hp and improvement of Hp-induced chronic active gastritis on administration of CJA.

本文言語English
ページ(範囲)337-341
ページ数5
ジャーナルAsian Pacific Journal of Cancer Prevention
6
3
出版ステータスPublished - 01-01-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 疫学
  • 腫瘍学
  • 公衆衛生学、環境および労働衛生
  • 癌研究

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