Surgical treatment of intramedullary spinal cord tumors: Prognosis and complications

M. Nakamura, K. Ishii, K. Watanabe, Takashi Tsuji, H. Takaishi, M. Matsumoto, Y. Toyama, K. Chiba

研究成果: Article

70 引用 (Scopus)

抄録

Study design: Retrospective case series. Objective: To evaluate our recent treatment strategy for intramedullary spinal cord tumors. Setting: Department of Orthopaedic Surgery, Keio University, Japan. Methods: We reviewed 68 cases of intramedullary tumors (ependymoma, 33; astrocytoma, 23; hemangioblastoma, 12), treated surgically between 1994 and 2003. There were 42 males and 26 females whose mean age at the time of surgery was 43 years. The mean follow-up period was 6.2 years. The tumor malignancy grade according to the WHO classification was astrocytoma grade I, 3; grade II, 8 (low-grade: 11 cases); grade III, 10; grade IV, 2 (high-grade: 12 cases). All ependymomas were grade II. Three of the 12 hemangioblastomas were associated with von Hippel-Lindau disease. Results: Total excision was achieved in 90% of the ependymomas and functional improvement was obtained when the preoperative neurological deficit was mild. Approximately 50% of low-grade astrocytomas could be totally excised with favorable survival outcomes, suggesting that total excision should be attempted for low-grade astrocytomas. However, total excision of high-grade tumors was difficult and the functional outcomes were poor. Cordotomy should be considered in patients with a thoracic high-grade astrocytoma. Total resection was possible in 92% of hemangioblastoma, and the functional outcomes were good, however, more attention should be paid for tumors with feeding arteries on the ventral side and for those associated with von Hippel-Lindau disease. Conclusions: Predictors of good surgical outcome for intramedullary spinal cord tumors were histological grades of the tumors, surgical margins, and neurological status of the patient before surgery.

元の言語English
ページ(範囲)282-286
ページ数5
ジャーナルSpinal Cord
46
発行部数4
DOI
出版物ステータスPublished - 11-04-2008

Fingerprint

Spinal Cord Neoplasms
Astrocytoma
Hemangioblastoma
Ependymoma
von Hippel-Lindau Disease
Neoplasms
Therapeutics
Cordotomy
Orthopedics
Japan
Thorax
Retrospective Studies
Arteries
Survival

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Nakamura, M., Ishii, K., Watanabe, K., Tsuji, T., Takaishi, H., Matsumoto, M., ... Chiba, K. (2008). Surgical treatment of intramedullary spinal cord tumors: Prognosis and complications. Spinal Cord, 46(4), 282-286. https://doi.org/10.1038/sj.sc.3102130
Nakamura, M. ; Ishii, K. ; Watanabe, K. ; Tsuji, Takashi ; Takaishi, H. ; Matsumoto, M. ; Toyama, Y. ; Chiba, K. / Surgical treatment of intramedullary spinal cord tumors : Prognosis and complications. :: Spinal Cord. 2008 ; 巻 46, 番号 4. pp. 282-286.
@article{94a837448f564924aac1b104df20ef31,
title = "Surgical treatment of intramedullary spinal cord tumors: Prognosis and complications",
abstract = "Study design: Retrospective case series. Objective: To evaluate our recent treatment strategy for intramedullary spinal cord tumors. Setting: Department of Orthopaedic Surgery, Keio University, Japan. Methods: We reviewed 68 cases of intramedullary tumors (ependymoma, 33; astrocytoma, 23; hemangioblastoma, 12), treated surgically between 1994 and 2003. There were 42 males and 26 females whose mean age at the time of surgery was 43 years. The mean follow-up period was 6.2 years. The tumor malignancy grade according to the WHO classification was astrocytoma grade I, 3; grade II, 8 (low-grade: 11 cases); grade III, 10; grade IV, 2 (high-grade: 12 cases). All ependymomas were grade II. Three of the 12 hemangioblastomas were associated with von Hippel-Lindau disease. Results: Total excision was achieved in 90{\%} of the ependymomas and functional improvement was obtained when the preoperative neurological deficit was mild. Approximately 50{\%} of low-grade astrocytomas could be totally excised with favorable survival outcomes, suggesting that total excision should be attempted for low-grade astrocytomas. However, total excision of high-grade tumors was difficult and the functional outcomes were poor. Cordotomy should be considered in patients with a thoracic high-grade astrocytoma. Total resection was possible in 92{\%} of hemangioblastoma, and the functional outcomes were good, however, more attention should be paid for tumors with feeding arteries on the ventral side and for those associated with von Hippel-Lindau disease. Conclusions: Predictors of good surgical outcome for intramedullary spinal cord tumors were histological grades of the tumors, surgical margins, and neurological status of the patient before surgery.",
author = "M. Nakamura and K. Ishii and K. Watanabe and Takashi Tsuji and H. Takaishi and M. Matsumoto and Y. Toyama and K. Chiba",
year = "2008",
month = "4",
day = "11",
doi = "10.1038/sj.sc.3102130",
language = "English",
volume = "46",
pages = "282--286",
journal = "Spinal Cord",
issn = "1362-4393",
publisher = "Nature Publishing Group",
number = "4",

}

Nakamura, M, Ishii, K, Watanabe, K, Tsuji, T, Takaishi, H, Matsumoto, M, Toyama, Y & Chiba, K 2008, 'Surgical treatment of intramedullary spinal cord tumors: Prognosis and complications', Spinal Cord, 巻. 46, 番号 4, pp. 282-286. https://doi.org/10.1038/sj.sc.3102130

Surgical treatment of intramedullary spinal cord tumors : Prognosis and complications. / Nakamura, M.; Ishii, K.; Watanabe, K.; Tsuji, Takashi; Takaishi, H.; Matsumoto, M.; Toyama, Y.; Chiba, K.

:: Spinal Cord, 巻 46, 番号 4, 11.04.2008, p. 282-286.

研究成果: Article

TY - JOUR

T1 - Surgical treatment of intramedullary spinal cord tumors

T2 - Prognosis and complications

AU - Nakamura, M.

AU - Ishii, K.

AU - Watanabe, K.

AU - Tsuji, Takashi

AU - Takaishi, H.

AU - Matsumoto, M.

AU - Toyama, Y.

AU - Chiba, K.

PY - 2008/4/11

Y1 - 2008/4/11

N2 - Study design: Retrospective case series. Objective: To evaluate our recent treatment strategy for intramedullary spinal cord tumors. Setting: Department of Orthopaedic Surgery, Keio University, Japan. Methods: We reviewed 68 cases of intramedullary tumors (ependymoma, 33; astrocytoma, 23; hemangioblastoma, 12), treated surgically between 1994 and 2003. There were 42 males and 26 females whose mean age at the time of surgery was 43 years. The mean follow-up period was 6.2 years. The tumor malignancy grade according to the WHO classification was astrocytoma grade I, 3; grade II, 8 (low-grade: 11 cases); grade III, 10; grade IV, 2 (high-grade: 12 cases). All ependymomas were grade II. Three of the 12 hemangioblastomas were associated with von Hippel-Lindau disease. Results: Total excision was achieved in 90% of the ependymomas and functional improvement was obtained when the preoperative neurological deficit was mild. Approximately 50% of low-grade astrocytomas could be totally excised with favorable survival outcomes, suggesting that total excision should be attempted for low-grade astrocytomas. However, total excision of high-grade tumors was difficult and the functional outcomes were poor. Cordotomy should be considered in patients with a thoracic high-grade astrocytoma. Total resection was possible in 92% of hemangioblastoma, and the functional outcomes were good, however, more attention should be paid for tumors with feeding arteries on the ventral side and for those associated with von Hippel-Lindau disease. Conclusions: Predictors of good surgical outcome for intramedullary spinal cord tumors were histological grades of the tumors, surgical margins, and neurological status of the patient before surgery.

AB - Study design: Retrospective case series. Objective: To evaluate our recent treatment strategy for intramedullary spinal cord tumors. Setting: Department of Orthopaedic Surgery, Keio University, Japan. Methods: We reviewed 68 cases of intramedullary tumors (ependymoma, 33; astrocytoma, 23; hemangioblastoma, 12), treated surgically between 1994 and 2003. There were 42 males and 26 females whose mean age at the time of surgery was 43 years. The mean follow-up period was 6.2 years. The tumor malignancy grade according to the WHO classification was astrocytoma grade I, 3; grade II, 8 (low-grade: 11 cases); grade III, 10; grade IV, 2 (high-grade: 12 cases). All ependymomas were grade II. Three of the 12 hemangioblastomas were associated with von Hippel-Lindau disease. Results: Total excision was achieved in 90% of the ependymomas and functional improvement was obtained when the preoperative neurological deficit was mild. Approximately 50% of low-grade astrocytomas could be totally excised with favorable survival outcomes, suggesting that total excision should be attempted for low-grade astrocytomas. However, total excision of high-grade tumors was difficult and the functional outcomes were poor. Cordotomy should be considered in patients with a thoracic high-grade astrocytoma. Total resection was possible in 92% of hemangioblastoma, and the functional outcomes were good, however, more attention should be paid for tumors with feeding arteries on the ventral side and for those associated with von Hippel-Lindau disease. Conclusions: Predictors of good surgical outcome for intramedullary spinal cord tumors were histological grades of the tumors, surgical margins, and neurological status of the patient before surgery.

UR - http://www.scopus.com/inward/record.url?scp=41849093380&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41849093380&partnerID=8YFLogxK

U2 - 10.1038/sj.sc.3102130

DO - 10.1038/sj.sc.3102130

M3 - Article

C2 - 17909556

AN - SCOPUS:41849093380

VL - 46

SP - 282

EP - 286

JO - Spinal Cord

JF - Spinal Cord

SN - 1362-4393

IS - 4

ER -

Nakamura M, Ishii K, Watanabe K, Tsuji T, Takaishi H, Matsumoto M その他. Surgical treatment of intramedullary spinal cord tumors: Prognosis and complications. Spinal Cord. 2008 4 11;46(4):282-286. https://doi.org/10.1038/sj.sc.3102130