Synergistic upregulation of inducible nitric oxide synthase and cyclooxygenase-2 in gastric mucosa of mongolian gerbils by a high-salt diet and Helicobacter pylori infection

T. Toyoda, T. Tsukamoto, N. Hirano, T. Mizoshita, S. Kato, S. Takasu, H. Ban, M. Tatematsu

研究成果: Article

22 引用 (Scopus)

抜粋

Aims: The intake of salt and salty food is known as a risk factor for gastric cancer. We have previously demonstrated that a high-salt diet dose-dependently enhances Helicobacter pylori (H. pylori)-associated gastritis and stomach carcinogenesis in Mongolian gerbils. In this study, we focused on the influence of excessive salt intake on the expression of inflammatory mediators involved in progression of H. pylori-induced chronic gastritis. Methods and Results: A total of 45 stomach samples from Mongolian gerbils were evaluated by immunohistochemistry. The animals were infected with H. pylori and fed basal (0.32%) or a high-salt (10%) diet, and sacrificed after 40 weeks. Proliferative activity and expression of cyclooxygenase-2 (COX-2) in gastric mucosa were significantly increased in H. pylori-infected gerbils. The additional high-salt diet significantly up-regulated the expression of inducible nitric oxide synthase (iNOS) and COX-2 in H. pylori-infected groups (P<0.01 and P<0.05, respectively), while no significant effects were noted in non-infected animals. There was significant synergistic interaction between H. pylori infection and 10% NaCl diet on the expression of iNOS (P<0.05) and also a tendency for enhanced COX-2 expression (P=0.0599). Conclusions: The present results suggest that a high-salt diet works synergistically with H. pylori infection to enhance iNOS and COX-2 expression in the gastric mucosa of Mongolian gerbils, and support the hypothesis that excessive salt intake may be associated with progression of H. pylori-induced gastritis.

元の言語English
ページ(範囲)593-599
ページ数7
ジャーナルHistology and Histopathology
23
発行部数5
出版物ステータスPublished - 01-05-2008
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

フィンガープリント Synergistic upregulation of inducible nitric oxide synthase and cyclooxygenase-2 in gastric mucosa of mongolian gerbils by a high-salt diet and Helicobacter pylori infection' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用