Synthesis of capuramycin and its analogues via a Ferrier-type I reaction and their biological evaluation

Shintaro Kusaka, Kazuki Yamamoto, Motoko Shinohara, Yusuke Minato, Satoshi Ichikawa

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

The total synthesis of capuramycin (1), which is a promising anti-tubercular antibiotics, has been accomplished using Ferrier-type I reaction as a key step. This total synthesis is an alternative approach to the synthesis of capuramycin and its analogues. The 3′-O-demethyl analogue (2), which exhibits an equivalent antibacterial activity as capuramycin (1) against Mycobacterium smegmatis and Mycobacterium avium, is suggested to have potential as a lead structure of capuramycin analogues because 2 is more accessible from a synthetic view point.

本文言語英語
論文番号117011
ジャーナルBioorganic and Medicinal Chemistry
73
DOI
出版ステータス出版済み - 01-11-2022

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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