Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis

Yasuhiro Horita, Takemasa Takii, Taku Chiba, Ryuji Kuroishi, Yasuhiro Maeda, Yukihisa Kurono, Emi Inagaki, Kenji Nishimura, Yoshifumi Yamamoto, Chiyoji Abe, Masami Mori, Kikuo Onozaki

研究成果: Article査読

20 被引用数 (Scopus)

抄録

A series of sugar derivatives (1-13) were synthesized and evaluated for antibacterial activity against Mycobacterium tuberculosis (MTB), especially multi-drug resistant (MDR) MTB, and the structure-activity relationships of these compounds were studied. The results showed that the compound OCT313 (2-acetamido-2deoxy-β-d-glucopyranosyl N,N-dimethyldithiocarbamate) (4) exhibited significant in vitro bactericidal activity, and that the dithiocarbamate group at C-1 position of the glucopyranoside ring was requisite for the antibacterial activity.

本文言語English
ページ(範囲)6313-6316
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
19
22
DOI
出版ステータスPublished - 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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