Targeting the Hippo signalling pathway for cancer treatment

Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Hiroki Goto, Wakako Kato, Hirofumi Omori, Yosuke Miyachi, Hideru Togashi, Yohei Shimono, Akira Suzuki

研究成果: Review article査読

24 被引用数 (Scopus)

抄録

The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced patient survival. Thus, the Hippo pathway is an attractive anti-cancer target. Here, we provide an overview of the function and regulation of Hippo signalling components and summarize progress to date on the development of agents able to regulate Hippo signalling for cancer therapy.

本文言語English
ページ(範囲)237-244
ページ数8
ジャーナルJournal of Biochemistry
161
3
DOI
出版ステータスPublished - 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

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