Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease

Sawako Kato, Paul G. Shiels, Dagmara McGuinness, Bengt Lindholm, Peter Stenvinkel, Louise Nordfors, Abdul Rashid Qureshi, Yukio Yuzawa, Seiichi Matsuo, Shoichi Maruyama

研究成果: Article

5 引用 (Scopus)

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Aims: To analyze changes in telomere length (TL) after dialysis initiation. Methods: In 59 Japanese incident dialysis patients, associations between TL in peripheral blood leukocytes, inflammatory biomarkers and nutritional status at baseline and changes in TL during 1 year of dialysis, were investigated. Results: Whereas relative TL decreased by 8.6% (median 14.4%), TL elongation occurred in 16 patients (27%). Change in TL (ΔTL), defined as TL at 1 year minus TL at baseline, was associated with baseline TL (ρ = -0.70, p < 0.0001) and leukocyte count (ρ = 0.26, p = 0.044). In a logistic regression model, baseline TL (p < 0.0001) and leukocyte count (p = 0.047) were associated with ΔTL. Conclusions: TL shortening was observed in most incident dialysis patients. In 16 of the 59 patients, TL elongation occurred, possibly reflecting a more robust biological aging in patients whose naïve leukocytes may have undergone less proliferation to replace lost leukocytes.

元の言語English
ページ(範囲)25-33
ページ数9
ジャーナルBlood Purification
41
発行部数1-3
DOI
出版物ステータスPublished - 01-03-2016

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

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    Kato, S., Shiels, P. G., McGuinness, D., Lindholm, B., Stenvinkel, P., Nordfors, L., Qureshi, A. R., Yuzawa, Y., Matsuo, S., & Maruyama, S. (2016). Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease. Blood Purification, 41(1-3), 25-33. https://doi.org/10.1159/000440971