Telomere length as a potential biomarker of coronary artery disease

Joyeeta Bhattacharyya, Keichiro Mihara, Deborshi Bhattacharjee, Manjarí Mukherjee

研究成果: Review article査読

18 被引用数 (Scopus)

抄録

Coronary artery disease (CAD) is a multifactorial disease whose prevalence remains unabated especially in developing countries. Both lifestyle factors and genetic predisposition contribute to this disorder. Though notable achievements have been made in the medical, interventional and surgical management of CAD, the need for its prevention is more important. Among other modalities, this calls for defining evidence-based new biomarkers, which on their own or in combination with other known biomarkers may predict the risk of CAD to enable institution of appropriate preventive strategies. In the present communication, we have discussed the usefulness of shortening of telomeres as a potential biomarker of CAD. Clinical research evidence in favour of telomere shortening in CAD is well documented in different ethnic populations of the world. Establishing a well-standardized and accurate method of evaluating telomere length is essential before its routine use in preventive cardiology.

本文言語English
ページ(範囲)730-737
ページ数8
ジャーナルIndian Journal of Medical Research
145
June
DOI
出版ステータスPublished - 06-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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