Temperature-Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis

Michio Ohta; Nobuo Kido; Yasuaki Fujii; Yoshichika Arakawa; Takayuki Komatsu; Nobuo Kato

doi:10.1111/j.1348-0421.1987.tb01359.x

Temperature-Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis

Michio Ohta
, Nobuo Kido
, Yasuaki Fujii
, Yoshichika Arakawa
, Takayuki Komatsu
, Nobuo Kato

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

抄録

Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to pro-liferate at 37 C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.

本文言語	英語
ページ（範囲）	1259-1265
ページ数	7
ジャーナル	MICROBIOLOGY and IMMUNOLOGY
巻	31
号	12
DOI	https://doi.org/10.1111/j.1348-0421.1987.tb01359.x
出版ステータス	出版済み - 1987
外部発表	はい

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All Science Journal Classification (ASJC) codes

微生物学
免疫学
ウイルス学

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10.1111/j.1348-0421.1987.tb01359.x

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title = "Temperature-Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis",

abstract = "Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to pro-liferate at 37 C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.",

author = "Michio Ohta and Nobuo Kido and Yasuaki Fujii and Yoshichika Arakawa and Takayuki Komatsu and Nobuo Kato",

year = "1987",

doi = "10.1111/j.1348-0421.1987.tb01359.x",

language = "English",

volume = "31",

pages = "1259--1265",

journal = "MICROBIOLOGY and IMMUNOLOGY",

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TY - JOUR

T1 - Temperature-Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis

AU - Ohta, Michio

AU - Kido, Nobuo

AU - Fujii, Yasuaki

AU - Arakawa, Yoshichika

AU - Komatsu, Takayuki

AU - Kato, Nobuo

PY - 1987

Y1 - 1987

N2 - Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to pro-liferate at 37 C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.

AB - Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to pro-liferate at 37 C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.

UR - https://www.scopus.com/pages/publications/0023605886

UR - https://www.scopus.com/pages/publications/0023605886#tab=citedBy

U2 - 10.1111/j.1348-0421.1987.tb01359.x

DO - 10.1111/j.1348-0421.1987.tb01359.x

M3 - Article

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AN - SCOPUS:0023605886

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VL - 31

SP - 1259

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JO - MICROBIOLOGY and IMMUNOLOGY

JF - MICROBIOLOGY and IMMUNOLOGY

IS - 12

ER -

Temperature-Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis

抄録

UN SDG

All Science Journal Classification (ASJC) codes

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