Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study

Takashi Kanbayashi, Tetsuo Shimizu, Yuji Takahashi, Tsuyoshi Kitajima, Ken Ichi Takahashi, Yasushi Saito, Yasuo Hishikawa

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Polysomnography was used to assess the effect of thalidomide on human sleep. This compound significantly increased the time spent in REM and stage 3-4 sleep as compared with placebo. On the other hand, thalidomide significantly decreased the time spent in stage 1, while the time spent in stage 2 was unchanged. The effect of thalidomide on REM and stage 3-4 sleep is unique as compared with other hypnotics. Although the mode of action of this compound is unknown, further studies on thalidomide should help in our understanding of the mechanisms of sleep regulation.

本文言語English
ページ(範囲)113-115
ページ数3
ジャーナルSleep
22
1
DOI
出版ステータスPublished - 01-02-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 臨床神経学
  • 生理学(医学)

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