The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

Hinako Usui; Nagahide Takahashi; Shinichi Saito; Ryoko Ishihara; Nagisa Aoyama; Masashi Ikeda; Tatsuyo Suzuki; Tsuyoshi Kitajima; Yoshio Yamanouchi; Yoko Kinoshita; Keizo Yoshida; Nakao Iwata; Toshiya Inada; Norio Ozaki

doi:10.1016/j.schres.2006.07.019

The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

Hinako Usui
, Nagahide Takahashi
, Shinichi Saito
, Ryoko Ishihara
, Nagisa Aoyama
, Masashi Ikeda
, Tatsuyo Suzuki
, Tsuyoshi Kitajima
, Yoshio Yamanouchi
, Yoko Kinoshita
, Keizo Yoshida
, Nakao Iwata
, Toshiya Inada
, Norio Ozaki

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

抄録

Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.

本文言語	英語
ページ（範囲）	245-250
ページ数	6
ジャーナル	Schizophrenia Research
巻	88
号	1-3
DOI	https://doi.org/10.1016/j.schres.2006.07.019
出版ステータス	出版済み - 12-2006

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All Science Journal Classification (ASJC) codes

精神医学および精神衛生
生物学的精神医学

文献へのアクセス

10.1016/j.schres.2006.07.019

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引用スタイル

Usui, H., Takahashi, N., Saito, S., Ishihara, R., Aoyama, N., Ikeda, M., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Yoshida, K., Iwata, N., Inada, T., & Ozaki, N. (2006). The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. Schizophrenia Research, 88(1-3), 245-250. https://doi.org/10.1016/j.schres.2006.07.019

@article{9e9d3a41ea7c4a7dbee076d8b75e563c,

title = "The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population",

abstract = "Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.",

keywords = "CNP, Haplotypes, Linkage disequilibrium, OLIG2, Schizophrenia",

author = "Hinako Usui and Nagahide Takahashi and Shinichi Saito and Ryoko Ishihara and Nagisa Aoyama and Masashi Ikeda and Tatsuyo Suzuki and Tsuyoshi Kitajima and Yoshio Yamanouchi and Yoko Kinoshita and Keizo Yoshida and Nakao Iwata and Toshiya Inada and Norio Ozaki",

note = "Funding Information: We thank Y. Nakamura for the technical support. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Ministry of Health, Labor, and Welfare of Japan, and the Japan Health Sciences Foundation (Research on Health Sciences Focusing on Drug Innovation).",

year = "2006",

month = dec,

doi = "10.1016/j.schres.2006.07.019",

language = "English",

volume = "88",

pages = "245--250",

journal = "Schizophrenia Research",

issn = "0920-9964",

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}

Usui, H, Takahashi, N, Saito, S, Ishihara, R, Aoyama, N, Ikeda, M, Suzuki, T, Kitajima, T, Yamanouchi, Y, Kinoshita, Y, Yoshida, K, Iwata, N, Inada, T & Ozaki, N 2006, 'The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population', Schizophrenia Research, vol. 88, no. 1-3, pp. 245-250. https://doi.org/10.1016/j.schres.2006.07.019

The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. / Usui, Hinako; Takahashi, Nagahide; Saito, Shinichi その他.
In: Schizophrenia Research, Vol. 88, No. 1-3, 12.2006, p. 245-250.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

TY - JOUR

T1 - The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

AU - Usui, Hinako

AU - Takahashi, Nagahide

AU - Saito, Shinichi

AU - Ishihara, Ryoko

AU - Aoyama, Nagisa

AU - Ikeda, Masashi

AU - Suzuki, Tatsuyo

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Yoshida, Keizo

AU - Iwata, Nakao

AU - Inada, Toshiya

AU - Ozaki, Norio

N1 - Funding Information: We thank Y. Nakamura for the technical support. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Ministry of Health, Labor, and Welfare of Japan, and the Japan Health Sciences Foundation (Research on Health Sciences Focusing on Drug Innovation).

PY - 2006/12

Y1 - 2006/12

N2 - Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.

AB - Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.

KW - CNP

KW - Haplotypes

KW - Linkage disequilibrium

KW - OLIG2

KW - Schizophrenia

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