The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Ayako Kurimoto, Shinobu Kitazume, Yasuhiko Kizuka, Kazuki Nakajima, Ritsuko Oka, Reiko Fujinawa, Hiroaki Korekane, Yoshiki Yamaguchi, Yoshinao Wada, Naoyuki Taniguchi

研究成果: Article査読

30 被引用数 (Scopus)

抄録

Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.

本文言語English
ページ(範囲)11704-11714
ページ数11
ジャーナルJournal of Biological Chemistry
289
17
DOI
出版ステータスPublished - 25-04-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 細胞生物学

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