The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Ayako Kurimoto; Shinobu Kitazume; Yasuhiko Kizuka; Kazuki Nakajima; Ritsuko Oka; Reiko Fujinawa; Hiroaki Korekane; Yoshiki Yamaguchi; Yoshinao Wada; Naoyuki Taniguchi

doi:10.1074/jbc.M113.502542

The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Ayako Kurimoto
, Shinobu Kitazume
, Yasuhiko Kizuka
, Kazuki Nakajima
, Ritsuko Oka
, Reiko Fujinawa
, Hiroaki Korekane
, Yoshiki Yamaguchi
, Yoshinao Wada
, Naoyuki Taniguchi

客員教員

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

46 被引用数 (Scopus)

抄録

Background: Little is known about how loss of a given glycan causes adaptive regulation of other glycosylation. Results: Deficiency in core α1,6-fucose specifically up-regulates bisecting GlcNAc by enhanced gene expression of a biosynthetic enzyme GnT-III. Conclusion: Wnt signaling pathway regulates the expression of GnT-III. Significance: Wnt-mediated GnT-III up-regulation may be an adaptive response to the loss of core fucose.

本文言語	英語
ページ（範囲）	11704-11714
ページ数	11
ジャーナル	Journal of Biological Chemistry
巻	289
号	17
DOI	https://doi.org/10.1074/jbc.M113.502542
出版ステータス	出版済み - 25-04-2014

All Science Journal Classification (ASJC) codes

生化学
分子生物学
細胞生物学

文献へのアクセス

10.1074/jbc.M113.502542

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引用スタイル

Kurimoto, A., Kitazume, S., Kizuka, Y., Nakajima, K., Oka, R., Fujinawa, R., Korekane, H., Yamaguchi, Y., Wada, Y., & Taniguchi, N. (2014). The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function. Journal of Biological Chemistry, 289(17), 11704-11714. https://doi.org/10.1074/jbc.M113.502542

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author = "Ayako Kurimoto and Shinobu Kitazume and Yasuhiko Kizuka and Kazuki Nakajima and Ritsuko Oka and Reiko Fujinawa and Hiroaki Korekane and Yoshiki Yamaguchi and Yoshinao Wada and Naoyuki Taniguchi",

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Kurimoto, A, Kitazume, S, Kizuka, Y, Nakajima, K, Oka, R, Fujinawa, R, Korekane, H, Yamaguchi, Y, Wada, Y & Taniguchi, N 2014, 'The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function', Journal of Biological Chemistry, vol. 289, no. 17, pp. 11704-11714. https://doi.org/10.1074/jbc.M113.502542

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AU - Fujinawa, Reiko

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