In view of the fact that antidepressant drugs have almost no effect on a normal person's emotion and behavior, it seems necessary to examine their effects on animal behavior under abnormal, or stressful conditions. When mice were put into a water wheel apparatus, they tried to escape from the water by turning the wheel. This 'wheel-turning behavior' was activated by repeated doses of imipramine or amitriptyline. The increase was paralleled by a reduction of brain β-adrenergic receptor binding. It was speculated that chronic doses of antidepressants would increase escape behavior in mice when they were placed in a critical situation. The causal relationships between this behavioral change and β-receptor function in brain remains to be further examined.
|ジャーナル||Japanese Journal of Psychopharmacology|
|出版ステータス||Published - 1984|
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