The activation of mice's behavior and reduction of brain β-adrenergic receptor binding following repeated administration of antidepressant drugs

S. Nomura, J. Shimizu, N. Ukei, S. Sakaida, T. Nakazawa

研究成果: Article査読

3 被引用数 (Scopus)

抄録

In view of the fact that antidepressant drugs have almost no effect on a normal person's emotion and behavior, it seems necessary to examine their effects on animal behavior under abnormal, or stressful conditions. When mice were put into a water wheel apparatus, they tried to escape from the water by turning the wheel. This 'wheel-turning behavior' was activated by repeated doses of imipramine or amitriptyline. The increase was paralleled by a reduction of brain β-adrenergic receptor binding. It was speculated that chronic doses of antidepressants would increase escape behavior in mice when they were placed in a critical situation. The causal relationships between this behavioral change and β-receptor function in brain remains to be further examined.

本文言語English
ページ(範囲)237-241
ページ数5
ジャーナルJapanese Journal of Psychopharmacology
4
3
出版ステータスPublished - 1984

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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