The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population

Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sora

研究成果: Article

16 引用 (Scopus)

抄録

Background: Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors. We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis.Methods: We first analyzed variations in the exons and exon-intron boundaries of the ADORA2A gene in METH dependent/psychotic patients. Then an association analysis between these single nucleotide polymorphisms and METH dependence/psychosis was performed using a total of 171 METH dependent/psychotic patients and 229 controls.Results: We found 6 variations, of which one single nucleotide polymorphism (SNP) was novel. Significant associations were observed between the allelic and genotypic frequencies of the Exon2+751 (rs5751876) SNP and METH dependence/psychosis. These associations were observed especially in females. In the clinical feature analyses, significant associations were observed between the SNP and the patient subgroup using METH alone (i.e., without concomitant use of other substances of abuse).Conclusions: These results suggest that the ADORA2A gene could be a vulnerability factor for METH dependence/psychosis, especially in females and/or in patients using only METH.

元の言語English
記事番号50
ジャーナルBehavioral and Brain Functions
6
DOI
出版物ステータスPublished - 30-08-2010

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Adenosine A2A Receptors
Methamphetamine
Psychotic Disorders
Population
Single Nucleotide Polymorphism
Exons
Genes
Purinergic P1 Receptors
Dopamine Receptors
Genetic Predisposition to Disease
Introns
Nervous System
Substance-Related Disorders

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Biological Psychiatry
  • Behavioral Neuroscience

これを引用

Kobayashi, Hideaki ; Ujike, Hiroshi ; Iwata, Nakao ; Inada, Toshiya ; Yamada, Mitsuhiko ; Sekine, Yoshimoto ; Uchimura, Naohisa ; Iyo, Masaomi ; Ozaki, Norio ; Itokawa, Masanari ; Sora, Ichiro. / The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population. :: Behavioral and Brain Functions. 2010 ; 巻 6.
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abstract = "Background: Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors. We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis.Methods: We first analyzed variations in the exons and exon-intron boundaries of the ADORA2A gene in METH dependent/psychotic patients. Then an association analysis between these single nucleotide polymorphisms and METH dependence/psychosis was performed using a total of 171 METH dependent/psychotic patients and 229 controls.Results: We found 6 variations, of which one single nucleotide polymorphism (SNP) was novel. Significant associations were observed between the allelic and genotypic frequencies of the Exon2+751 (rs5751876) SNP and METH dependence/psychosis. These associations were observed especially in females. In the clinical feature analyses, significant associations were observed between the SNP and the patient subgroup using METH alone (i.e., without concomitant use of other substances of abuse).Conclusions: These results suggest that the ADORA2A gene could be a vulnerability factor for METH dependence/psychosis, especially in females and/or in patients using only METH.",
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Kobayashi, H, Ujike, H, Iwata, N, Inada, T, Yamada, M, Sekine, Y, Uchimura, N, Iyo, M, Ozaki, N, Itokawa, M & Sora, I 2010, 'The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population', Behavioral and Brain Functions, 巻. 6, 50. https://doi.org/10.1186/1744-9081-6-50

The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population. / Kobayashi, Hideaki; Ujike, Hiroshi; Iwata, Nakao; Inada, Toshiya; Yamada, Mitsuhiko; Sekine, Yoshimoto; Uchimura, Naohisa; Iyo, Masaomi; Ozaki, Norio; Itokawa, Masanari; Sora, Ichiro.

:: Behavioral and Brain Functions, 巻 6, 50, 30.08.2010.

研究成果: Article

TY - JOUR

T1 - The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population

AU - Kobayashi, Hideaki

AU - Ujike, Hiroshi

AU - Iwata, Nakao

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Sekine, Yoshimoto

AU - Uchimura, Naohisa

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Itokawa, Masanari

AU - Sora, Ichiro

PY - 2010/8/30

Y1 - 2010/8/30

N2 - Background: Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors. We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis.Methods: We first analyzed variations in the exons and exon-intron boundaries of the ADORA2A gene in METH dependent/psychotic patients. Then an association analysis between these single nucleotide polymorphisms and METH dependence/psychosis was performed using a total of 171 METH dependent/psychotic patients and 229 controls.Results: We found 6 variations, of which one single nucleotide polymorphism (SNP) was novel. Significant associations were observed between the allelic and genotypic frequencies of the Exon2+751 (rs5751876) SNP and METH dependence/psychosis. These associations were observed especially in females. In the clinical feature analyses, significant associations were observed between the SNP and the patient subgroup using METH alone (i.e., without concomitant use of other substances of abuse).Conclusions: These results suggest that the ADORA2A gene could be a vulnerability factor for METH dependence/psychosis, especially in females and/or in patients using only METH.

AB - Background: Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors. We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis.Methods: We first analyzed variations in the exons and exon-intron boundaries of the ADORA2A gene in METH dependent/psychotic patients. Then an association analysis between these single nucleotide polymorphisms and METH dependence/psychosis was performed using a total of 171 METH dependent/psychotic patients and 229 controls.Results: We found 6 variations, of which one single nucleotide polymorphism (SNP) was novel. Significant associations were observed between the allelic and genotypic frequencies of the Exon2+751 (rs5751876) SNP and METH dependence/psychosis. These associations were observed especially in females. In the clinical feature analyses, significant associations were observed between the SNP and the patient subgroup using METH alone (i.e., without concomitant use of other substances of abuse).Conclusions: These results suggest that the ADORA2A gene could be a vulnerability factor for METH dependence/psychosis, especially in females and/or in patients using only METH.

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