The ameliorative effects of a hypnotic bromvalerylurea in sepsis

Satoshi Kikuchi, Tasuku Nishihara, Shun Kawasaki, Naoki Abe, Jun Kuwabara, Mohammed E. Choudhury, Hisaaki Takahashi, Hajime Yano, Takumi Nagaro, Yuji Watanabe, Mayuki Aibiki, Junya Tanaka

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Sepsis is a severe pathologic event, frequently causing death in critically ill patients. However, there are no approved drugs to treat sepsis, despite clinical trials of many agents that have distinct targets. Therefore, a novel effective treatment should be developed based on the pathogenesis of sepsis. We recently observed that an old hypnotic drug, bromvalerylurea (BU) suppressed expression of many kinds of pro- and anti-inflammatory mediators in LPS- or interferon-γ activated alveolar and peritoneal macrophages (AMs and PMs). Taken the anti-inflammatory effects of BU on macrophages, we challenged it to septic rats that had been subjected to cecum-ligation and puncture (CLP). BU was subcutaneously administered to septic rats twice per day. Seven days after CLP treatment, 85% of septic rats administrated vehicle had died, whereas administration of BU reduce the rate to 50%. Septic rats showed symptoms of multi-organ failure; respiratory, circulatory and renal system failures as revealed by histopathological analyses, blood gas test and others. BU ameliorated these symptoms. BU also prevented elevated serum-IL-6 level as well as IL-6 mRNA expression in septic rats. Collectively, BU might be a novel agent to ameliorate sepsis by preventing the onset of MOF.

本文言語English
ページ(範囲)319-326
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
459
2
DOI
出版ステータスPublished - 03-04-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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