The antagonistic effects of naloxone on cycloheximide and anisomicin-induced amnesia

Tsutomu Kameyama, Toshitaka Nabeshima, Teruo Kozawa

研究成果: Article

17 引用 (Scopus)

抄録

The amnesia induced by cycloheximide (CXM) injected SC and by CXM or anisomycin injected ICV immediately after the training test was antagonized in combination with an opiate antagonist, naloxone (NLX). This antagonism occurred on both the passive avoidance- and escape-learning responses in a dose-dependent manner in mice. NLX alone (0.3-10.0 mg/kg) did not alter the performances of these tasks. Furthermore, the decrease in retention performance on shuttle avoidance in rats induced by CXM was also antagonized by NLX. Treatment with CXM and/or NLX did not affect spontaneous locomotor activity. The interaction of these drugs on the performance of the passive avoidance- and escape-learning and the shuttle avoidance tasks may be related to neurochemical memory processes. These results suggest than an opioid system may participate in the amnesic actions induced by protein synthesis inhibitors in these models.

元の言語English
ページ(範囲)567-572
ページ数6
ジャーナルPharmacology, Biochemistry and Behavior
25
発行部数3
DOI
出版物ステータスPublished - 01-01-1986
外部発表Yes

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Amnesia
Cycloheximide
Naloxone
Avoidance Learning
Opiate Alkaloids
Anisomycin
Protein Synthesis Inhibitors
Task Performance and Analysis
Locomotion
Drug Interactions
Opioid Analgesics
Rats
Data storage equipment
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

これを引用

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The antagonistic effects of naloxone on cycloheximide and anisomicin-induced amnesia. / Kameyama, Tsutomu; Nabeshima, Toshitaka; Kozawa, Teruo.

:: Pharmacology, Biochemistry and Behavior, 巻 25, 番号 3, 01.01.1986, p. 567-572.

研究成果: Article

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