The antagonistic effects of naloxone on cycloheximide and anisomicin-induced amnesia

Tsutomu Kameyama, Toshitaka Nabeshima, Teruo Kozawa

研究成果: ジャーナルへの寄稿学術論文査読

19 被引用数 (Scopus)

抄録

The amnesia induced by cycloheximide (CXM) injected SC and by CXM or anisomycin injected ICV immediately after the training test was antagonized in combination with an opiate antagonist, naloxone (NLX). This antagonism occurred on both the passive avoidance- and escape-learning responses in a dose-dependent manner in mice. NLX alone (0.3-10.0 mg/kg) did not alter the performances of these tasks. Furthermore, the decrease in retention performance on shuttle avoidance in rats induced by CXM was also antagonized by NLX. Treatment with CXM and/or NLX did not affect spontaneous locomotor activity. The interaction of these drugs on the performance of the passive avoidance- and escape-learning and the shuttle avoidance tasks may be related to neurochemical memory processes. These results suggest than an opioid system may participate in the amnesic actions induced by protein synthesis inhibitors in these models.

本文言語英語
ページ(範囲)567-572
ページ数6
ジャーナルPharmacology, Biochemistry and Behavior
25
3
DOI
出版ステータス出版済み - 09-1986
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 毒物学
  • 薬理学
  • 臨床生化学
  • 生物学的精神医学
  • 行動神経科学

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