The assessment of prognostic factors for lung metastasectomy in colorectal cancer patients with previously resected liver metastases

Ayumi Hachimaru, Ryo Maeda, Takashi Suda, Yasushi Takagi

研究成果: Article査読

抄録

The purpose of this study is to investigate the prognostic factors of lung metastasectomy in patients with previously resected liver metastases. Thirty-three patients underwent complete resection of lung metastases after previous liver metastasectomy from colorectal cancer between January 2004 and December 2013. In univariate analyses, all cumulative survival curves were estimated using the Kaplan-Meier method, and differences in variables were evaluated using the log-rank test. Multivariate analyses were performed using the Cox proportional hazards regression model. The 5-year survival rate of all 33 patients after lung metastasectomy was 31%. Univariate analysis identified 2 significant prognostic factors: preoperative serum carcinoembryonic antigen level (P ¼ 0.035) and maximum tumor size (P ¼ 0.029). Subgroup analysis with a combination of these 2 independent prognostic factors revealed 2-year survival rates of 100%, 92.3%, and 0% for patients with 0, 1, and 2 risk factors, respectively. We identified 2 independent poor prognostic factors for pulmonary metastasectomy in patients with previously resected liver metastases: high serum carcinoembryonic antigen level before lung metastasectomy, and maximum size of lung metastases. When these 2 factors are combined, higher- and lower-risk subgroups can be identified, which may help select patients with previously resected liver metastases who benefit most from lung metastasectomy.

本文言語English
ページ(範囲)453-460
ページ数8
ジャーナルInternational Surgery
104
9-10
DOI
出版ステータスPublished - 09-2019

All Science Journal Classification (ASJC) codes

  • 外科

フィンガープリント

「The assessment of prognostic factors for lung metastasectomy in colorectal cancer patients with previously resected liver metastases」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル