The Association Between Plaque Characterization by CT Angiography and Post-Procedural Myocardial Infarction in Patients With Elective Stent Implantation

Tadayuki Uetani, Tetsuya Amano, Ayako Kunimura, Soichiro Kumagai, Hirohiko Ando, Kiminobu Yokoi, Tomohiro Yoshida, Bunichi Kato, Masataka Kato, Nobuyuki Marui, Michio Nanki, Tatsuaki Matsubara, Hideki Ishii, Hideo Izawa, Toyoaki Murohara

研究成果: Article

44 引用 (Scopus)

抄録

Objectives: This study sought to evaluate the association between volumetric characterization of target lesions by multidetector computed tomography (MDCT) angiography and the risk of post-procedural myocardial injury after elective stent implantation. Background: Previous reports have shown that plaque characterization of the target lesion may provide useful information for stratifying the risk of coronary stenting. Methods: A total of 189 consecutive patients were enrolled; they underwent elective stent implantation after volumetric plaque analysis with 64-slice MDCT. Each plaque component and lumen (filled with dye) was defined as follows: 1) low-attenuation plaque (LAP) (<50 HU); 2) moderate-attenuation plaque (MAP) (50 to 150 HU); 3) lumen (151 to 500 HU); and 4) high-attenuation plaque (HAP) (>500 HU). The volume of each plaque component in the target lesion was calculated using Color Code Plaque. Post-procedural creatine kinase-MB isoform and troponin-T (TnT) at 18 h after percutaneous coronary intervention were also evaluated. Results: The volumes of LAP (87.9 ± 94.8 mm3 vs. 47.4 ± 43.7 mm3, p < 0.01) and MAP (111.6 ± 77.5 mm3 vs. 89.8 ± 67.1 mm3, p < 0.05) were larger in patients with post-procedural myocardial injury (defined as positive TnT) than in those with negative TnT. The volumes of LAP and MAP and fraction of LAP in total plaque (LAP volume/total plaque volume) correlated with biomarkers; the MAP fraction was inversely correlated with biomarkers. The volume of LAP was an independent predictor of positive TnT after adjusting for patient background, conventional IVUS parameters, and procedural factors. Conclusions: Post-procedural myocardial injury was associated with the volume and fraction of LAP as detected by MDCT. The volume of LAP was an independent predictor of positive TnT. Plaque analysis by MDCT would be a useful method for predicting post-procedural myocardial injury after percutaneous coronary intervention.

元の言語English
ページ(範囲)19-28
ページ数10
ジャーナルJACC: Cardiovascular Imaging
3
発行部数1
DOI
出版物ステータスPublished - 01-01-2010
外部発表Yes

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Troponin T
Multidetector Computed Tomography
Stents
Myocardial Infarction
Wounds and Injuries
Percutaneous Coronary Intervention
Biomarkers
MB Form Creatine Kinase
Protein Isoforms
Coloring Agents
Color
Computed Tomography Angiography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

これを引用

Uetani, Tadayuki ; Amano, Tetsuya ; Kunimura, Ayako ; Kumagai, Soichiro ; Ando, Hirohiko ; Yokoi, Kiminobu ; Yoshida, Tomohiro ; Kato, Bunichi ; Kato, Masataka ; Marui, Nobuyuki ; Nanki, Michio ; Matsubara, Tatsuaki ; Ishii, Hideki ; Izawa, Hideo ; Murohara, Toyoaki. / The Association Between Plaque Characterization by CT Angiography and Post-Procedural Myocardial Infarction in Patients With Elective Stent Implantation. :: JACC: Cardiovascular Imaging. 2010 ; 巻 3, 番号 1. pp. 19-28.
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abstract = "Objectives: This study sought to evaluate the association between volumetric characterization of target lesions by multidetector computed tomography (MDCT) angiography and the risk of post-procedural myocardial injury after elective stent implantation. Background: Previous reports have shown that plaque characterization of the target lesion may provide useful information for stratifying the risk of coronary stenting. Methods: A total of 189 consecutive patients were enrolled; they underwent elective stent implantation after volumetric plaque analysis with 64-slice MDCT. Each plaque component and lumen (filled with dye) was defined as follows: 1) low-attenuation plaque (LAP) (<50 HU); 2) moderate-attenuation plaque (MAP) (50 to 150 HU); 3) lumen (151 to 500 HU); and 4) high-attenuation plaque (HAP) (>500 HU). The volume of each plaque component in the target lesion was calculated using Color Code Plaque. Post-procedural creatine kinase-MB isoform and troponin-T (TnT) at 18 h after percutaneous coronary intervention were also evaluated. Results: The volumes of LAP (87.9 ± 94.8 mm3 vs. 47.4 ± 43.7 mm3, p < 0.01) and MAP (111.6 ± 77.5 mm3 vs. 89.8 ± 67.1 mm3, p < 0.05) were larger in patients with post-procedural myocardial injury (defined as positive TnT) than in those with negative TnT. The volumes of LAP and MAP and fraction of LAP in total plaque (LAP volume/total plaque volume) correlated with biomarkers; the MAP fraction was inversely correlated with biomarkers. The volume of LAP was an independent predictor of positive TnT after adjusting for patient background, conventional IVUS parameters, and procedural factors. Conclusions: Post-procedural myocardial injury was associated with the volume and fraction of LAP as detected by MDCT. The volume of LAP was an independent predictor of positive TnT. Plaque analysis by MDCT would be a useful method for predicting post-procedural myocardial injury after percutaneous coronary intervention.",
author = "Tadayuki Uetani and Tetsuya Amano and Ayako Kunimura and Soichiro Kumagai and Hirohiko Ando and Kiminobu Yokoi and Tomohiro Yoshida and Bunichi Kato and Masataka Kato and Nobuyuki Marui and Michio Nanki and Tatsuaki Matsubara and Hideki Ishii and Hideo Izawa and Toyoaki Murohara",
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Uetani, T, Amano, T, Kunimura, A, Kumagai, S, Ando, H, Yokoi, K, Yoshida, T, Kato, B, Kato, M, Marui, N, Nanki, M, Matsubara, T, Ishii, H, Izawa, H & Murohara, T 2010, 'The Association Between Plaque Characterization by CT Angiography and Post-Procedural Myocardial Infarction in Patients With Elective Stent Implantation', JACC: Cardiovascular Imaging, 巻. 3, 番号 1, pp. 19-28. https://doi.org/10.1016/j.jcmg.2009.09.016

The Association Between Plaque Characterization by CT Angiography and Post-Procedural Myocardial Infarction in Patients With Elective Stent Implantation. / Uetani, Tadayuki; Amano, Tetsuya; Kunimura, Ayako; Kumagai, Soichiro; Ando, Hirohiko; Yokoi, Kiminobu; Yoshida, Tomohiro; Kato, Bunichi; Kato, Masataka; Marui, Nobuyuki; Nanki, Michio; Matsubara, Tatsuaki; Ishii, Hideki; Izawa, Hideo; Murohara, Toyoaki.

:: JACC: Cardiovascular Imaging, 巻 3, 番号 1, 01.01.2010, p. 19-28.

研究成果: Article

TY - JOUR

T1 - The Association Between Plaque Characterization by CT Angiography and Post-Procedural Myocardial Infarction in Patients With Elective Stent Implantation

AU - Uetani, Tadayuki

AU - Amano, Tetsuya

AU - Kunimura, Ayako

AU - Kumagai, Soichiro

AU - Ando, Hirohiko

AU - Yokoi, Kiminobu

AU - Yoshida, Tomohiro

AU - Kato, Bunichi

AU - Kato, Masataka

AU - Marui, Nobuyuki

AU - Nanki, Michio

AU - Matsubara, Tatsuaki

AU - Ishii, Hideki

AU - Izawa, Hideo

AU - Murohara, Toyoaki

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Objectives: This study sought to evaluate the association between volumetric characterization of target lesions by multidetector computed tomography (MDCT) angiography and the risk of post-procedural myocardial injury after elective stent implantation. Background: Previous reports have shown that plaque characterization of the target lesion may provide useful information for stratifying the risk of coronary stenting. Methods: A total of 189 consecutive patients were enrolled; they underwent elective stent implantation after volumetric plaque analysis with 64-slice MDCT. Each plaque component and lumen (filled with dye) was defined as follows: 1) low-attenuation plaque (LAP) (<50 HU); 2) moderate-attenuation plaque (MAP) (50 to 150 HU); 3) lumen (151 to 500 HU); and 4) high-attenuation plaque (HAP) (>500 HU). The volume of each plaque component in the target lesion was calculated using Color Code Plaque. Post-procedural creatine kinase-MB isoform and troponin-T (TnT) at 18 h after percutaneous coronary intervention were also evaluated. Results: The volumes of LAP (87.9 ± 94.8 mm3 vs. 47.4 ± 43.7 mm3, p < 0.01) and MAP (111.6 ± 77.5 mm3 vs. 89.8 ± 67.1 mm3, p < 0.05) were larger in patients with post-procedural myocardial injury (defined as positive TnT) than in those with negative TnT. The volumes of LAP and MAP and fraction of LAP in total plaque (LAP volume/total plaque volume) correlated with biomarkers; the MAP fraction was inversely correlated with biomarkers. The volume of LAP was an independent predictor of positive TnT after adjusting for patient background, conventional IVUS parameters, and procedural factors. Conclusions: Post-procedural myocardial injury was associated with the volume and fraction of LAP as detected by MDCT. The volume of LAP was an independent predictor of positive TnT. Plaque analysis by MDCT would be a useful method for predicting post-procedural myocardial injury after percutaneous coronary intervention.

AB - Objectives: This study sought to evaluate the association between volumetric characterization of target lesions by multidetector computed tomography (MDCT) angiography and the risk of post-procedural myocardial injury after elective stent implantation. Background: Previous reports have shown that plaque characterization of the target lesion may provide useful information for stratifying the risk of coronary stenting. Methods: A total of 189 consecutive patients were enrolled; they underwent elective stent implantation after volumetric plaque analysis with 64-slice MDCT. Each plaque component and lumen (filled with dye) was defined as follows: 1) low-attenuation plaque (LAP) (<50 HU); 2) moderate-attenuation plaque (MAP) (50 to 150 HU); 3) lumen (151 to 500 HU); and 4) high-attenuation plaque (HAP) (>500 HU). The volume of each plaque component in the target lesion was calculated using Color Code Plaque. Post-procedural creatine kinase-MB isoform and troponin-T (TnT) at 18 h after percutaneous coronary intervention were also evaluated. Results: The volumes of LAP (87.9 ± 94.8 mm3 vs. 47.4 ± 43.7 mm3, p < 0.01) and MAP (111.6 ± 77.5 mm3 vs. 89.8 ± 67.1 mm3, p < 0.05) were larger in patients with post-procedural myocardial injury (defined as positive TnT) than in those with negative TnT. The volumes of LAP and MAP and fraction of LAP in total plaque (LAP volume/total plaque volume) correlated with biomarkers; the MAP fraction was inversely correlated with biomarkers. The volume of LAP was an independent predictor of positive TnT after adjusting for patient background, conventional IVUS parameters, and procedural factors. Conclusions: Post-procedural myocardial injury was associated with the volume and fraction of LAP as detected by MDCT. The volume of LAP was an independent predictor of positive TnT. Plaque analysis by MDCT would be a useful method for predicting post-procedural myocardial injury after percutaneous coronary intervention.

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DO - 10.1016/j.jcmg.2009.09.016

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JO - JACC: Cardiovascular Imaging

JF - JACC: Cardiovascular Imaging

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