The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients

Tomomitsu Tahara, Tomoyuki Shibata, Tomiyasu Arisawa, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Hiromi Yamashita, Hiroshi Nakano, Ichiro Hirata

研究成果: Article

5 引用 (Scopus)

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Background: Heat-shock protein (HSP) 70 plays essential roles in cellular response to a variety of environmental stresses or unfavorable conditions. A to G transition at the 1267 position of the HSP70-2 gene confers different levels of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of premalignant condition, on the degree of acute or chronic inflammation in the stomach. Patients and Methods: A total of 378 individuals participated in this study. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene. Prevalence of intestinal metaplasia was investigated histologically and the degree of histological gastritis in the antrum was classified according to the updated Sydney System. Results: Although a direct association was not observed between HSP70-2 polymorphism and prevalence of intestinal metaplasia, a significant association was found between the BB genotype and lower metaplasia score in individuals who were Helicobacter pylori (H. pylori) positive and aged 60 years or older (BB vs. A carriers; 0.84±0.95 vs. 1.23±1.01, p=0.0197). When individuals were divided into 3 groups according to the severity of gastric mucosal atrophy: non-atrophic gastritis (NA) group (atrophy score=0 and metaplasia score=0), severe atrophic gastritis (SA) group (atrophy score≥2 or metaplasia score≥2), and mild atrophic gastritis (MA) group (all others), the BB genotype was associated with a lower risk of severe atrophy in the SA subgroup (adjusted odds ratio=0.37, 95% confidence interval =0.16-0.84, p=0.0172). Conclusion: The BB genotype of HSP70-2 gene is associated with a reduced risk of gastric pre-malignant condition in H. pylori-infected older individuals.

元の言語English
ページ(範囲)3453-3458
ページ数6
ジャーナルAnticancer research
29
発行部数8
出版物ステータスPublished - 01-08-2009

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HSP70 Heat-Shock Proteins
Metaplasia
Helicobacter pylori
Stomach
Atrophic Gastritis
Genotype
Atrophy
Genes
Gastritis
Restriction Fragment Length Polymorphisms
Odds Ratio
Confidence Intervals
Inflammation
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Tahara, Tomomitsu ; Shibata, Tomoyuki ; Arisawa, Tomiyasu ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Okubo, Masaaki ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Fujita, Hiroshi ; Nagasaka, Mitsuo ; Iwata, Masami ; Yamashita, Hiromi ; Nakano, Hiroshi ; Hirata, Ichiro. / The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. :: Anticancer research. 2009 ; 巻 29, 番号 8. pp. 3453-3458.
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title = "The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients",
abstract = "Background: Heat-shock protein (HSP) 70 plays essential roles in cellular response to a variety of environmental stresses or unfavorable conditions. A to G transition at the 1267 position of the HSP70-2 gene confers different levels of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of premalignant condition, on the degree of acute or chronic inflammation in the stomach. Patients and Methods: A total of 378 individuals participated in this study. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene. Prevalence of intestinal metaplasia was investigated histologically and the degree of histological gastritis in the antrum was classified according to the updated Sydney System. Results: Although a direct association was not observed between HSP70-2 polymorphism and prevalence of intestinal metaplasia, a significant association was found between the BB genotype and lower metaplasia score in individuals who were Helicobacter pylori (H. pylori) positive and aged 60 years or older (BB vs. A carriers; 0.84±0.95 vs. 1.23±1.01, p=0.0197). When individuals were divided into 3 groups according to the severity of gastric mucosal atrophy: non-atrophic gastritis (NA) group (atrophy score=0 and metaplasia score=0), severe atrophic gastritis (SA) group (atrophy score≥2 or metaplasia score≥2), and mild atrophic gastritis (MA) group (all others), the BB genotype was associated with a lower risk of severe atrophy in the SA subgroup (adjusted odds ratio=0.37, 95{\%} confidence interval =0.16-0.84, p=0.0172). Conclusion: The BB genotype of HSP70-2 gene is associated with a reduced risk of gastric pre-malignant condition in H. pylori-infected older individuals.",
author = "Tomomitsu Tahara and Tomoyuki Shibata and Tomiyasu Arisawa and Masakatsu Nakamura and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Hiroshi Fujita and Mitsuo Nagasaka and Masami Iwata and Hiromi Yamashita and Hiroshi Nakano and Ichiro Hirata",
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Tahara, T, Shibata, T, Arisawa, T, Nakamura, M, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Fujita, H, Nagasaka, M, Iwata, M, Yamashita, H, Nakano, H & Hirata, I 2009, 'The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients', Anticancer research, 巻. 29, 番号 8, pp. 3453-3458.

The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. / Tahara, Tomomitsu; Shibata, Tomoyuki; Arisawa, Tomiyasu; Nakamura, Masakatsu; Yoshioka, Daisuke; Okubo, Masaaki; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Fujita, Hiroshi; Nagasaka, Mitsuo; Iwata, Masami; Yamashita, Hiromi; Nakano, Hiroshi; Hirata, Ichiro.

:: Anticancer research, 巻 29, 番号 8, 01.08.2009, p. 3453-3458.

研究成果: Article

TY - JOUR

T1 - The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Arisawa, Tomiyasu

AU - Nakamura, Masakatsu

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Yamashita, Hiromi

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background: Heat-shock protein (HSP) 70 plays essential roles in cellular response to a variety of environmental stresses or unfavorable conditions. A to G transition at the 1267 position of the HSP70-2 gene confers different levels of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of premalignant condition, on the degree of acute or chronic inflammation in the stomach. Patients and Methods: A total of 378 individuals participated in this study. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene. Prevalence of intestinal metaplasia was investigated histologically and the degree of histological gastritis in the antrum was classified according to the updated Sydney System. Results: Although a direct association was not observed between HSP70-2 polymorphism and prevalence of intestinal metaplasia, a significant association was found between the BB genotype and lower metaplasia score in individuals who were Helicobacter pylori (H. pylori) positive and aged 60 years or older (BB vs. A carriers; 0.84±0.95 vs. 1.23±1.01, p=0.0197). When individuals were divided into 3 groups according to the severity of gastric mucosal atrophy: non-atrophic gastritis (NA) group (atrophy score=0 and metaplasia score=0), severe atrophic gastritis (SA) group (atrophy score≥2 or metaplasia score≥2), and mild atrophic gastritis (MA) group (all others), the BB genotype was associated with a lower risk of severe atrophy in the SA subgroup (adjusted odds ratio=0.37, 95% confidence interval =0.16-0.84, p=0.0172). Conclusion: The BB genotype of HSP70-2 gene is associated with a reduced risk of gastric pre-malignant condition in H. pylori-infected older individuals.

AB - Background: Heat-shock protein (HSP) 70 plays essential roles in cellular response to a variety of environmental stresses or unfavorable conditions. A to G transition at the 1267 position of the HSP70-2 gene confers different levels of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of premalignant condition, on the degree of acute or chronic inflammation in the stomach. Patients and Methods: A total of 378 individuals participated in this study. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene. Prevalence of intestinal metaplasia was investigated histologically and the degree of histological gastritis in the antrum was classified according to the updated Sydney System. Results: Although a direct association was not observed between HSP70-2 polymorphism and prevalence of intestinal metaplasia, a significant association was found between the BB genotype and lower metaplasia score in individuals who were Helicobacter pylori (H. pylori) positive and aged 60 years or older (BB vs. A carriers; 0.84±0.95 vs. 1.23±1.01, p=0.0197). When individuals were divided into 3 groups according to the severity of gastric mucosal atrophy: non-atrophic gastritis (NA) group (atrophy score=0 and metaplasia score=0), severe atrophic gastritis (SA) group (atrophy score≥2 or metaplasia score≥2), and mild atrophic gastritis (MA) group (all others), the BB genotype was associated with a lower risk of severe atrophy in the SA subgroup (adjusted odds ratio=0.37, 95% confidence interval =0.16-0.84, p=0.0172). Conclusion: The BB genotype of HSP70-2 gene is associated with a reduced risk of gastric pre-malignant condition in H. pylori-infected older individuals.

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M3 - Article

C2 - 19661373

AN - SCOPUS:68549140016

VL - 29

SP - 3453

EP - 3458

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 8

ER -