The Bysl gene product, bystin, is essential for survival of mouse embryos

Rui Aoki, Nao Suzuki, Bibhash C. Paria, Kazuhiro Sugihara, Tomoya O. Akama, Gerhard Raab, Masaya Miyoshi, Daita Nadano, Michiko N. Fukuda

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re-appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl, resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos.

本文言語English
ページ(範囲)6062-6068
ページ数7
ジャーナルFEBS Letters
580
26
DOI
出版ステータスPublished - 13-11-2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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